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Sympathomimetic nasal decongestant (Phenethylamine group)
Phenpromethamine (former brand name Vonedrine ), also known as N ,β-dimethylphenethylamine , is a
sympathomimetic
nasal decongestant of the
phenethylamine group.
[1]
[2]
[3]
[4] It was previously marketed as a
nasal inhaler from 1943 through 1960 but is no longer available.
[4]
[3]
[5] The medication is a
stimulant and is banned by the
World Anti-Doping Agency .
[6]
[3] It has been detected in
dietary supplements starting in the 2010s.
[5]
[4]
See also
References
^ Weston AW, Ruddy AW, Suter CM (1943). "The Condensation of Unsaturated Amines with Aromatic Compounds. The Preparation of β-Substituted Phenethylamines". Journal of the American Chemical Society . 65 (4): 674–677.
doi :
10.1021/ja01244a049 .
ISSN
0002-7863 .
^ Elks J (14 November 2014).
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 971–.
ISBN
978-1-4757-2085-3 .
^
a
b
c Docherty JR (June 2008).
"Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)" . British Journal of Pharmacology . 154 (3): 606–22.
doi :
10.1038/bjp.2008.124 .
PMC
2439527 .
PMID
18500382 .
^
a
b
c Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ (March 2021). "Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine". Clinical Toxicology . 59 (11): 975–981.
doi :
10.1080/15563650.2021.1894333 .
PMID
33755516 .
S2CID
232338883 .
^
a
b Tsumura Y, Kiguchi A, Komatsuzaki S, Ieuji K (2019).
"A novel method to distinguish β-methylphenylethylamines from isomeric α-methylphenylethylamines by liquid chromatography coupled to electrospray ionization mass spectrometry" . Forensic Toxicology . 38 (2): 465–474.
doi :
10.1007/s11419-019-00511-z .
ISSN
1860-8965 .
S2CID
212828763 .
^
"The 2006 WADA Prohibited List: Summary of Revisions" (PDF) . 2006 Canadian Centre for Ethics in Sport Advisory Notice . Archived from
the original (PDF) on 11 April 2007.
DRAs Tooltip Dopamine releasing agents
NRAs Tooltip Norepinephrine releasing agents
SRAs Tooltip Serotonin releasing agents
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