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Protein-coding gene in the species Homo sapiens
Interleukin 34 (IL-34) is a
protein belonging to a group of
cytokines called
interleukins. It was originally identified in humans, by large scale screening of
secreted
proteins; chimpanzee, murine, rat and chicken interleukin 34
orthologs have also been found. The protein is composed of 241
amino acids, 39
kilodaltons in mass, and forms
homodimers. IL-34 increases growth or survival of immune cells known as
monocytes; it elicits its activity by binding the
Colony stimulating factor 1 receptor.
Messenger RNA (mRNA) expression of human IL-34 is most abundant in
spleen but occurs in several other tissues:
thymus,
liver,
small intestine,
colon,
prostate gland,
lung,
heart,
brain,
kidney,
testes, and
ovary. The discovery of IL-34 protein in the
red pulp of the spleen suggests involvement in growth and development of
myeloid cells, consistent with its activity on monocytes.
[5]
References
External links
- Overview of all the structural information available in the
PDB for
UniProt:
Q6ZMJ4 (Human Interleukin-34) at the
PDBe-KB.
- Overview of all the structural information available in the
PDB for
UniProt:
Q8R1R4 (Mouse Interleukin-34) at the
PDBe-KB.
Interleukin-34 at the U.S. National Library of Medicine
Medical Subject Headings (MeSH)
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By family | |
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By function/ cell | |
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Chemokine | |
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CSF | |
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Interferon |
IFNAR (α/β, I) |
- Agonists:
Albinterferon
-
Interferon alpha (interferon alfa, IFN-α)
-
Interferon alfa (
IFNA1,
IFNA2,
IFNA4,
IFNA5,
IFNA6,
IFNA7,
IFNA8,
IFNA10,
IFNA13,
IFNA14,
IFNA16,
IFNA17,
IFNA21)
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Interferon alfa 2a
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Interferon alfa 2b
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Interferon alfa n1
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Interferon alfacon-1
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Interferon alpha-n3
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Interferon beta (IFN-β) (
IFNB1,
IFNB3)
-
Interferon beta 1a
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Interferon beta 1b
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Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
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Interferon omega (IFN-ω, IFNW1)
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Peginterferon alfa-2a
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Peginterferon alfa-2b
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IFNGR (γ, II) | |
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IFNLR (λ, III) |
- See IL-28R (IFNLR)
here instead.
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Interleukin | |
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TGFβ | |
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TNF | |
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Others | |
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