From Wikipedia, the free encyclopedia
Type of cytokine produced primarily by monocytes and macrophages
A monokine is a type of
cytokine
[1] produced primarily by
monocytes and
macrophages .
Some monokines are:
Functions
Monokines released from
macrophages can attract
neutrophils , via the process
chemotaxis .
The secretion of monokine, prompted by interferon gamma, has activity for the receptors found within immune cells, such as
T-cells , hindering their ability to function as regulators of the body. Thus, promoting tumor progression in the cancer-state.
[4] In fact, its activity is important in other diseases, such as pulmonary
tuberculosis , where researchers have identified monokine as a biomarker.
[5]
See also
References
^
Monokines at the U.S. National Library of Medicine
Medical Subject Headings (MeSH)
^
a
b Leung DY, Geha RS, Newburger JW (1986).
"Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome" . The Journal of Experimental Medicine . 164 (6): 1958–72.
doi :
10.1084/jem.164.6.1958 .
PMC
2188474 .
PMID
3491174 .
^
a
b Julius M. Cruse; Robert Edwin Lewis (20 April 2009).
Illustrated dictionary of immunology . CRC Press. pp. 208–.
ISBN
978-0-8493-7987-1 . Retrieved 24 April 2011 .
^ Bolomsky, Arnold; Schreder, Martin; Hübl, Wolfgang; Zojer, Niklas; Hilbe, Wolfgang; Ludwig, Heinz (November 2016).
"Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma" . Leukemia & Lymphoma . 57 (11): 2516–2525.
doi :
10.3109/10428194.2016.1151511 .
ISSN
1042-8194 .
PMID
26999330 .
^ Li, Yang; He, Dengqi; Che, Yinfu; Zhao, Xinchen (2020-11-20).
"Monokine induced by gamma interferon for detecting pulmonary tuberculosis: A diagnostic meta-analysis" . Medicine . 99 (47): e23302.
doi :
10.1097/MD.0000000000023302 .
ISSN
0025-7974 .
PMC
7676613 .
PMID
33217864 .
External links
By family
By function/ cell
Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others