Monoclonal antibody | |
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Type | Whole antibody |
Source | Mouse |
Target | IL-6 |
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Elsilimomab (also known as B-E8) is a mouse monoclonal antibody. [1] B-E8 was developed by Diaclone, [2] a French company which produces many mouse monoclonal antibodies.
It (OPR-003) targets (and blocks) Interleukin-6. [3]
It has undergone a number of early stage clinical trials, e.g. for lymphoma and myeloma. [4]
It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339. [4]
p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer