From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
C-C motif chemokine 22 is a
protein that in humans is encoded by the CCL22
gene .
[4]
[5]
[6]
The
protein encoded by this gene is secreted by dendritic cells and
macrophages , and elicits its effects on its target cells by interacting with cell surface
chemokine receptors such as
CCR4 .
[7] The gene for CCL22 is located in human
chromosome 16 in a cluster with other chemokines called
CX3CL1 and
CCL17 .
[8]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000102962 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997).
"Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells" . J Exp Med . 185 (9): 1595–604.
doi :
10.1084/jem.185.9.1595 .
PMC
2196293 .
PMID
9151897 .
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet Cell Genet . 81 (1): 10–1.
doi :
10.1159/000015000 .
PMID
9691168 .
S2CID
46851784 .
^
"Entrez Gene: CCL22 chemokine (C-C motif) ligand 22" .
^ Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001).
"Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo" . Eur. J. Immunol . 31 (3): 812–22.
doi :
10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L .
hdl :
11379/240109 .
PMID
11241286 .
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet . 81 (1): 10–1.
doi :
10.1159/000015000 .
PMID
9691168 .
S2CID
46851784 .
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308.
doi :
10.1006/geno.1999.5927 .
PMID
10493829 .
Further reading
Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells". J. Leukoc. Biol . 71 (2): 173–83.
doi :
10.1189/jlb.71.2.173 .
PMID
11818437 .
S2CID
720060 .
Gear AR, Camerini D (2003). "Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense". Microcirculation . 10 (3–4): 335–50.
doi :
10.1038/sj.mn.7800198 .
PMID
12851650 .
S2CID
10791409 .
Chang M, McNinch J, Elias C, et al. (1997).
"Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes" . J. Biol. Chem . 272 (40): 25229–37.
doi :
10.1074/jbc.272.40.25229 .
PMID
9312138 .
Pal R, Garzino-Demo A, Markham PD, et al. (1997). "Inhibition of HIV-1 infection by the beta-chemokine MDC". Science . 278 (5338): 695–8.
Bibcode :
1997Sci...278..695P .
doi :
10.1126/science.278.5338.695 .
PMID
9381181 .
Imai T, Chantry D, Raport CJ, et al. (1998).
"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4" . J. Biol. Chem . 273 (3): 1764–8.
doi :
10.1074/jbc.273.3.1764 .
PMID
9430724 .
Struyf S, Proost P, Sozzani S, et al. (1998).
"Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor" . J. Immunol . 161 (6): 2672–5.
doi :
10.4049/jimmunol.161.6.2672 .
PMID
9743322 .
Meucci O, Fatatis A, Simen AA, et al. (1998).
"Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity" . Proc. Natl. Acad. Sci. U.S.A . 95 (24): 14500–5.
Bibcode :
1998PNAS...9514500M .
doi :
10.1073/pnas.95.24.14500 .
PMC
24402 .
PMID
9826729 .
Proost P, Struyf S, Schols D, et al. (1999).
"Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction" . J. Biol. Chem . 274 (7): 3988–93.
doi :
10.1074/jbc.274.7.3988 .
PMID
9933589 .
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308.
doi :
10.1006/geno.1999.5927 .
PMID
10493829 .
Annunziato F, Romagnani P, Cosmi L, et al. (2000).
"Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection" . J. Immunol . 165 (1): 238–46.
doi :
10.4049/jimmunol.165.1.238 .
PMID
10861057 .
Vulcano M, Albanesi C, Stoppacciaro A, et al. (2001).
"Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo" . Eur. J. Immunol . 31 (3): 812–22.
doi :
10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L .
hdl :
11379/240109 .
PMID
11241286 .
Berin MC, Dwinell MB, Eckmann L, Kagnoff MF (2001). "Production of MDC/CCL22 by human intestinal epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol . 280 (6): G1217–26.
doi :
10.1152/ajpgi.2001.280.6.G1217 .
PMID
11352815 .
S2CID
6628796 .
Lambeir AM, Proost P, Durinx C, et al. (2001).
"Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family" . J. Biol. Chem . 276 (32): 29839–45.
doi :
10.1074/jbc.M103106200 .
PMID
11390394 .
Wakahara S, Fujii Y, Nakao T, et al. (2002). "Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood". Cytokine . 16 (4): 143–52.
doi :
10.1006/cyto.2001.0958 .
PMID
11792124 .
Ghia P, Strola G, Granziero L, et al. (2002).
"Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22" . Eur. J. Immunol . 32 (5): 1403–13.
doi :
10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y .
PMID
11981828 .
D'Ambrosio D, Albanesi C, Lang R, et al. (2002).
"Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion" . J. Immunol . 169 (5): 2303–12.
doi :
10.4049/jimmunol.169.5.2303 .
PMID
12193695 .
Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003).
"Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans" . Int. Immunol . 14 (11): 1255–62.
doi :
10.1093/intimm/dxf098 .
PMID
12407016 .
External links
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By function/ cell