chemokine (C-C motif) ligand 15 | |||||||
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Identifiers | |||||||
Symbol | CCL15 | ||||||
Alt. symbols | SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B | ||||||
NCBI gene | 6359 | ||||||
HGNC | 10613 | ||||||
OMIM | 601393 | ||||||
PDB | 2HCC | ||||||
RefSeq | NM_032965 | ||||||
UniProt | Q16663 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. [1] It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. [2] [3] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14. [4]