From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
Chemokine (C-X-C motif ) ligand 13 (CXCL13 ), also known as B lymphocyte chemoattractant (BLC ) or B cell-attracting chemokine 1 (BCA-1 ), is a
protein
ligand that in humans is encoded by the CXCL13
gene .
[5]
[6]
Function
CXCL13 is a small
chemokine belonging to the
CXC chemokine family . As its other names suggest, this chemokine is selectively
chemotactic for
B cells belonging to both the
B-1 and
B-2 subsets , and elicits its effects by interacting with
chemokine receptor
CXCR5 .
[5]
[7] CXCL13 and its receptor CXCR5 control the organization of B cells within
follicles of
lymphoid tissues
[8] and is expressed highly in the
liver ,
spleen ,
lymph nodes , and
gut of
humans .
[5] The
gene for CXCL13 is located on human
chromosome 4 in a cluster of other CXC chemokines.
[6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called
follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000156234 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000023078 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
c Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998).
"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5" . J. Exp. Med . 187 (4): 655–60.
doi :
10.1084/jem.187.4.655 .
PMC
2212150 .
PMID
9463416 .
^
a
b Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature . 391 (6669): 799–803.
Bibcode :
1998Natur.391..799G .
doi :
10.1038/35876 .
PMID
9486651 .
S2CID
4373691 .
^ Ansel KM, Harris RB, Cyster JG (January 2002).
"CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity" . Immunity . 16 (1): 67–76.
doi :
10.1016/S1074-7613(01)00257-6 .
PMID
11825566 .
^ Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature . 406 (6793): 309–14.
doi :
10.1038/35018581 .
PMID
10917533 .
S2CID
4369622 .
^ de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007).
"The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells" . Blood . 109 (11): 4952–63.
doi :
10.1182/blood-2006-10-055145 .
PMID
17284527 .
External links
By family
By function/ cell