From Wikipedia, the free encyclopedia
Efavaleukin alfa is an experimental drug that works as an
interleukin-2 "mutein
Fc fusion protein that preferentially binds the high-affinity IL-2 receptor alpha chain (
CD25) to selectively promote
Treg expansion".
[1] It is developed to treat
systemic lupus erythematosus (SLE).
[2]
[3]
[4]
References
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^ Sarkar, N.; Hu, X.; Tchao, N.; Furie, R.; Kivitz, A.; Cohen, S.; Gorski, K. (1 June 2023).
"Op0140 Regulatory T Cell Defects in Sle and Therapy with a Novel Il-2 Mutein: Phase 1 Clinical Results with Efavaleukin Alfa". Annals of the Rheumatic Diseases. 82 (Suppl 1): 92–93.
doi:
10.1136/annrheumdis-2023-eular.369.
ISSN
0003-4967.
-
^ Cully, Megan (6 August 2021).
"T cell-regulating therapies for autoimmune diseases take FDA rejection in stride". Nature Reviews Drug Discovery. 20 (9): 655–657.
doi:
10.1038/d41573-021-00137-0.
-
^ Garces, Sandra; Karis, Elaine; Merrill, Joan T; Askanase, Anca D; Kalunian, Kenneth; Mo, May; Milmont, Cassandra E (July 2023).
"Improving resource utilisation in SLE drug development through innovative trial design". Lupus Science & Medicine. 10 (2): e000890.
doi:
10.1136/lupus-2022-000890.
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^ Tchao, N.; Sarkar, N.; Hu, X.; Zhang, R.; Milmont, C.; Jin, Y. Shi; Chow, V.; Kroenke, M.; Gorski, K.; Furie, R.; Kivitz, A.; Cohen, S. (1 June 2022).
"Ab0432 Efavaleukin Alfa, a Novel Il-2 Mutein, Selectively Expands Regulatory T Cells in Patients with Sle: Final Results of a Phase 1b Multiple Ascending Dose Study". Annals of the Rheumatic Diseases. 81 (Suppl 1): 1343–1344.
doi:
10.1136/annrheumdis-2022-eular.2244.
ISSN
0003-4967.