chemokine (C-C motif) ligand 13 | |||||||
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Identifiers | |||||||
Symbol | CCL13 | ||||||
Alt. symbols | SCYA13, MCP-4, NCC-1, SCYL1, CKb10 | ||||||
NCBI gene | 6357 | ||||||
HGNC | 10611 | ||||||
OMIM | 601391 | ||||||
RefSeq | NM_005408 | ||||||
UniProt | Q99616 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines. [1] [2] CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. [3] Activity of this chemokine has been implicated in allergic reactions such as asthma. [4] CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.