Prednicarbate

Prednicarbate
Clinical data
Other names	{2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl} propanoate
AHFS/ Drugs.com	Monograph
MedlinePlus	a604021
Routes of; administration	Topical
ATC code	D07AC18 ( WHO) ;
Identifiers
	IUPAC name 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate;
CAS Number	73771-04-7 ;
PubChem CID	6714002;
IUPHAR/BPS	7605;
DrugBank	DB01130 ;
ChemSpider	5145991 ;
UNII	V901LV1K7D;
ChEMBL	ChEMBL1200386 ;
CompTox Dashboard ( EPA)	DTXSID9045502 ;
ECHA InfoCard	100.070.516
Chemical and physical data
Formula	C27H36O8
Molar mass	488.577 g·mol−1
3D model ( JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC;
	InChI InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 ; Key:FNPXMHRZILFCKX-KAJVQRHHSA-N ;
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Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology; however, their tendency to produce side-effects has caused the need to search for new preparations.^[1]

It is nonhalogenated.^[2]

References

^ United States Pharmacopeia, the National Formulary. United States Pharmacopeial Convention, Incorporated. 2008. p. 3060. ISBN 978-1-889788-53-1.
^ Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.

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[1] United States Pharmacopeia, the National Formulary. United States Pharmacopeial Convention, Incorporated. 2008. p. 3060. ISBN 978-1-889788-53-1.

[pmid15657633-2] Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.

[1]

[2]

Clinical data

Other names	{2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl} propanoate
AHFS/ Drugs.com	Monograph
MedlinePlus	a604021
Routes of administration	Topical
ATC code	D07AC18 ( WHO)
Identifiers
IUPAC name 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate
CAS Number	73771-04-7^Y
PubChem CID	6714002
IUPHAR/BPS	7605
DrugBank	DB01130^N
ChemSpider	5145991^N
UNII	V901LV1K7D
ChEMBL	ChEMBL1200386^N
CompTox Dashboard ( EPA)	DTXSID9045502
ECHA InfoCard	100.070.516
Chemical and physical data
Formula	C₂₇H₃₆O₈
Molar mass	488.577 g·mol⁻¹
3D model ( JSmol)	Interactive image
SMILES O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC
InChI InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1^N Key:FNPXMHRZILFCKX-KAJVQRHHSA-N^N
^NY (what is this?) (verify)