From Wikipedia, the free encyclopedia
Chemical compound
PSNCBAM-1
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1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea
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CAS Number | |
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PubChem
CID | |
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ChemSpider | |
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UNII | |
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CompTox Dashboard (
EPA) | |
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Formula | C22H21ClN4O |
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Molar mass | 392.89 g·mol−1 |
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3D model (
JSmol) | |
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Clc1ccc(NC(=O)Nc2cccc(c2)c3cccc(n3)N4CCCC4)cc1
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InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28) Key:HDAYFSFWIPRJSO-UHFFFAOYSA-N
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PSNCBAM-1 is a negative
allosteric modulator of the
cannabinoid
CB1
receptor.
[1]
[2]
See also
References
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^ German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y (September 2014).
"Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)". Journal of Medicinal Chemistry. 57 (18): 7758–7769.
doi:
10.1021/jm501042u.
PMC
4175001.
PMID
25162172.
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^ Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P (November 2007).
"PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats". British Journal of Pharmacology. 152 (5): 805–814.
doi:
10.1038/sj.bjp.0707347.
PMC
2190018.
PMID
17592509.
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comparison) | Cannabibutols | |
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Quinolinyl esters | |
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Allosteric
CBRTooltip Cannabinoid receptor
ligands | |
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Endocannabinoid enhancers (inactivation inhibitors) | |
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Anticannabinoids (antagonists/inverse agonists/antibodies) | |
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Receptor (
ligands) |
CB1Tooltip Cannabinoid receptor type 1 | Agonists (abridged,
full list) | |
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Inverse agonists | |
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Antagonists | |
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CB2Tooltip Cannabinoid receptor type 2 | Agonists |
-
2-AG
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2-AGE (noladin ether)
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3,3'-Diindolylmethane
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4-O-Methylhonokiol
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α-Amyrin · β-Amyrin
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A-796,260
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A-834,735
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A-836,339
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AM-1172
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AM-1221
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AM-1235
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AM-1241
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AM-2232
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Anandamide
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AZ-11713908
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Cannabinol
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Caryophyllene
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CB-13
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CBS-0550
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CP 55,940
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GW-405,833 (L-768,242)
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GW-842,166X
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HU-308
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JTE 7-31
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JWH-007
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JWH-015
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JWH-018
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JWH-73
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JWH-133
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L-759,633
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L-759,656
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Lenabasum (anabasum)
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Magnolol
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MDA-19
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Nabitan
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NADA
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Olorinab (APD-371)
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PF-03550096
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S-444,823
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SER-601
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Serinolamide A
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UR-144
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Tedalinab
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THC (dronabinol)
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THCV
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Tetrahydromagnolol
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Virodhamine
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Antagonists | |
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NAGly (
GPR18) | |
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GPR55 | |
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GPR119 | |
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Transporter (
modulators) |
eCBTsTooltip Endocannabinoid transporter | |
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Enzyme (
modulators) | |
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Others |
- Others:
2-PG (directly potentiates activity of 2-AG at CB1 receptor)
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ARN-272 (FAAH-like anandamide transporter inhibitor)
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