O-774 is a classical
cannabinoid derivative which acts as a potent
agonist for the
cannabinoid receptors, with a
Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.[1][2]
^Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK (October 1998). "Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol". Journal of Medicinal Chemistry. 41 (22): 4400–7.
doi:
10.1021/jm9803875.
PMID9784115.
^Reggio PH, ed. (2009). "Cannabinoid Receptor Ligands and Structure-Activity Relationships.". The Cannabinoid Receptors. Part I. Humana Press. pp. 6–9.
ISBN978-1-58829-712-9.