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Chemical compound
JZP150
ATC code
Legal status
Metabolism CY3A4
N-pyridazin-3-yl-4-[(3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl)methylidene]piperidine-1-carboxamide
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (
EPA )
Formula C 23 H 20 F 3 N 5 O 2
Molar mass 455.441 g·mol−1 3D model (
JSmol )
n4ncccc4NC(=O)N(CC3)CC\C3=C/c2cc(ccc2)Oc(cc1)ncc1C(F)(F)F
InChI=1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)
Key:BATCTBJIJJEPHM-UHFFFAOYSA-N
JZP150 (formerly PF-04457845) is an inhibitor of the enzyme
fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both
analgesic and
antiinflammatory effects in animal studies comparable to
naproxen .
[1]
JZP150 is currently being developed by Jazz Pharmaceuticals and is in a Phase 2 trial in the US for PTSD. Patients will be given 0.3mg orally once per day for up to 12 weeks, or 4.0mg orally once per day for up to 12 weeks, or a placebo.
[2]
See also
References
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