From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
IL18RAP Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
3WO4
Identifiers
Aliases
IL18RAP , ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory proteinExternal IDs
OMIM :
604509 ;
MGI :
1338888 ;
HomoloGene :
2859 ;
GeneCards :
IL18RAP ;
OMA :
IL18RAP - orthologs
Wikidata
Interleukin 18 receptor accessory protein , also known as IL18RAP and CDw218b (
cluster of differentiation w218b), is a human
gene .
[5]
[6]
Function
The
protein encoded by this gene is an accessory subunit of the heterodimeric
receptor for
IL18 . This protein enhances the IL18 binding activity of
IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of
NF-κB and
MAPK8 (JNK) in response to IL18.
[5]
Disease association
Variants at IL18RAP have been linked to susceptibility to
Coeliac disease .
[7]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000115607 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026068 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: IL18RAP interleukin 18 receptor accessory protein" .
^ Born TL, Thomassen E, Bird TA, Sims JE (November 1998).
"Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling" . J. Biol. Chem . 273 (45): 29445–50.
doi :
10.1074/jbc.273.45.29445 .
PMID
9792649 .
^ Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008).
"Novel celiac disease genetic determinants related to the immune response" . Nat. Genet . 40 (4): 395–402.
doi :
10.1038/ng.102 .
PMC
2673512 .
PMID
18311140 .
Further reading
Born TL, Thomassen E, Bird TA, Sims JE (1998).
"Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling" . J. Biol. Chem . 273 (45): 29445–50.
doi :
10.1074/jbc.273.45.29445 .
PMID
9792649 .
Sareneva T, Julkunen I, Matikainen S (2000).
"IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells" . J. Immunol . 165 (4): 1933–8.
doi :
10.4049/jimmunol.165.4.1933 .
PMID
10925275 .
Mee JB, Alam Y, Groves RW (2000). "Human keratinocytes constitutively produce but do not process interleukin-18". Br. J. Dermatol . 143 (2): 330–6.
doi :
10.1046/j.1365-2133.2000.03759.x .
PMID
10951141 .
S2CID
44747360 .
Debets R, Timans JC, Churakowa T, et al. (2000).
"IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18" . J. Immunol . 165 (9): 4950–6.
doi :
10.4049/jimmunol.165.9.4950 .
PMID
11046021 .
Salvati VM, MacDonald TT, Bajaj-Elliott M, et al. (2002).
"Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease" . Gut . 50 (2): 186–90.
doi :
10.1136/gut.50.2.186 .
PMC
1773110 .
PMID
11788557 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Fukushima K, Ikehara Y, Yamashita K (2005).
"Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production" . J. Biol. Chem . 280 (18): 18056–62.
doi :
10.1074/jbc.M413297200 .
PMID
15760905 .
Hillier LW, Graves TA, Fulton RS, et al. (2005).
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31.
Bibcode :
2005Natur.434..724H .
doi :
10.1038/nature03466 .
PMID
15815621 .
Fiszer D, Rozwadowska N, Rychlewski L, et al. (2008). "Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues". Cytokine . 39 (3): 178–83.
doi :
10.1016/j.cyto.2007.07.186 .
PMID
17897836 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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