From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Macrophage-stimulating protein receptor is a
protein that in humans is encoded by the MST1R
gene .
[5]
[6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the
c-MET receptor tyrosine kinase.
[5]
[7]
Interactions
MST1R has been shown to
interact with
Grb2 .
[8]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000164078 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032584 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene . 8 (5): 1195–202.
PMID
8386824 .
^
"Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)" .
^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994).
"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP" . EMBO J . 13 (15): 3524–32.
doi :
10.1002/j.1460-2075.1994.tb06659.x .
PMC
395256 .
PMID
8062829 .
^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995).
"Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor" . Biochem. Biophys. Res. Commun . 216 (1): 110–8.
doi :
10.1006/bbrc.1995.2598 .
PMID
7488076 .
^ Iwama A, Yamaguchi N, Suda T (November 1996).
"STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family" . EMBO J . 15 (21): 5866–75.
doi :
10.1002/j.1460-2075.1996.tb00973.x .
PMC
452340 .
PMID
8918464 .
Further reading
Li BQ, Wang MH, Kung HF, et al. (1995).
"Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor" . Biochem. Biophys. Res. Commun . 216 (1): 110–8.
doi :
10.1006/bbrc.1995.2598 .
PMID
7488076 .
Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science . 266 (5182): 117–9.
Bibcode :
1994Sci...266..117W .
doi :
10.1126/science.7939629 .
PMID
7939629 .
Gaudino G, Follenzi A, Naldini L, et al. (1994).
"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP" . EMBO J . 13 (15): 3524–32.
doi :
10.1002/j.1460-2075.1994.tb06659.x .
PMC
395256 .
PMID
8062829 .
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene . 8 (12): 3403–10.
PMID
8247543 .
Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996).
"A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype" . Mol. Cell. Biol . 16 (10): 5518–26.
doi :
10.1128/MCB.16.10.5518 .
PMC
231551 .
PMID
8816464 .
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Iwama A, Yamaguchi N, Suda T (1997).
"STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family" . EMBO J . 15 (21): 5866–75.
doi :
10.1002/j.1460-2075.1996.tb00973.x .
PMC
452340 .
PMID
8918464 .
Sakamoto O, Iwama A, Amitani R, et al. (1997).
"Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility" . J. Clin. Invest . 99 (4): 701–9.
doi :
10.1172/JCI119214 .
PMC
507853 .
PMID
9045873 .
Follenzi A, Bakovic S, Gual P, et al. (2000).
"Cross-talk between the proto-oncogenes Met and Ron" . Oncogene . 19 (27): 3041–9.
doi :
10.1038/sj.onc.1203620 .
PMID
10871856 .
Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002).
"Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo" . Oncogene . 21 (41): 6382–6.
doi :
10.1038/sj.onc.1205783 .
PMID
12214279 .
Chen YQ, Zhou YQ, Fu LH, et al. (2002).
"Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais" . Carcinogenesis . 23 (11): 1811–9.
doi :
10.1093/carcin/23.11.1811 .
PMID
12419829 .
Zhou YQ, He C, Chen YQ, et al. (2003).
"Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential" . Oncogene . 22 (2): 186–97.
doi :
10.1038/sj.onc.1206075 .
PMID
12527888 .
Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003).
"Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4580–5.
Bibcode :
2003PNAS..100.4580D .
doi :
10.1073/pnas.0837136100 .
PMC
153598 .
PMID
12676986 .
Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol . 27 (6): 779–85.
doi :
10.1097/00000478-200306000-00008 .
PMID
12766581 .
S2CID
21112098 .
Penengo L, Rubin C, Yarden Y, Gaudino G (2003).
"c-Cbl is a critical modulator of the Ron tyrosine kinase receptor" . Oncogene . 22 (24): 3669–79.
doi :
10.1038/sj.onc.1206585 .
PMID
12802274 .
Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res . 288 (2): 382–9.
doi :
10.1016/S0014-4827(03)00250-7 .
PMID
12915129 .
Santoro MM, Gaudino G, Marchisio PC (2003).
"The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration" . Dev. Cell . 5 (2): 257–71.
doi :
10.1016/S1534-5807(03)00201-6 .
PMID
12919677 .
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004).
"The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation" . J. Biol. Chem . 279 (5): 3726–32.
doi :
10.1074/jbc.M309342200 .
PMID
14597639 .
van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004).
"Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors" . Blood . 103 (12): 4457–65.
doi :
10.1182/blood-2003-08-2713 .
PMID
14982882 .
S2CID
8097946 .
Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett . 20 (9): 2745–9.
doi :
10.1016/j.bmcl.2010.03.073 .
PMID
20363625 .
Activity Regulation Classification Kinetics Types
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)