From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Basal cell adhesion molecule , also known as
Lutheran antigen , is a
plasma membrane
glycoprotein that in humans is encoded by the BCAM
gene .
[5] BCAM has also recently been designated CD239 (
cluster of differentiation 239).
Function
Lutheran blood group glycoprotein is a member of the
immunoglobulin superfamily and a receptor for the extracellular matrix protein,
laminin . The protein contains five,
N-terminus , extracellular
immunoglobulin domains , a single transmembrane domain, and a short,
C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.
[5]
Interactions
BCAM has been shown to
interact with
Laminin, alpha 5 . BCAM has also been shown to promote the
metastasis of
ovarian cancer .
[6]
[7]
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000187244 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000002980 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)" .
^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001).
"Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity" . Blood . 97 (1): 312–20.
doi :
10.1182/blood.v97.1.312 .
PMID
11133776 .
S2CID
10715366 .
^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002).
"Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo" . J. Biol. Chem . 277 (47): 44864–9.
doi :
10.1074/jbc.M208731200 .
PMID
12244066 .
^ Sivakumar S, Lieber S, Librizzi D (2023).
"Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer" . Clin Transl Med . 13 (1): e1176.
doi :
10.1002/ctm2.1176 .
PMC
9842900 .
PMID
36647260 .
Further reading
Eyler CE, Telen MJ (2006). "The Lutheran glycoprotein: a multifunctional adhesion receptor". Transfusion . 46 (4): 668–77.
doi :
10.1111/j.1537-2995.2006.00779.x .
PMID
16584446 .
S2CID
37594599 .
Lewis M, Kaita H, Coghlan G, et al. (1989). "The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man". Ann. Hum. Genet . 52 (Pt 2): 137–44.
doi :
10.1111/j.1469-1809.1988.tb01089.x .
PMID
2907851 .
S2CID
26927877 .
Parsons SF, Mallinson G, Holmes CH, et al. (1995).
"The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver" . Proc. Natl. Acad. Sci. U.S.A . 92 (12): 5496–500.
Bibcode :
1995PNAS...92.5496P .
doi :
10.1073/pnas.92.12.5496 .
PMC
41722 .
PMID
7777537 .
Campbell IG, Foulkes WD, Senger G, et al. (1994). "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily". Cancer Res . 54 (22): 5761–5.
PMID
7954395 .
Rahuel C, Le Van Kim C, Mattei MG, et al. (1996).
"A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein" . Blood . 88 (5): 1865–72.
doi :
10.1182/blood.V88.5.1865.1865 .
PMID
8781446 .
Parsons SF, Mallinson G, Daniels GL, et al. (1997).
"Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms" . Blood . 89 (11): 4219–25.
doi :
10.1182/blood.V89.11.4219 .
PMID
9166867 .
El Nemer W, Rahuel C, Colin Y, et al. (1997).
"Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism" . Blood . 89 (12): 4608–16.
doi :
10.1182/blood.V89.12.4608 .
PMID
9192786 .
Parsons SF, Lee G, Spring FA, et al. (2001).
"Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity" . Blood . 97 (1): 312–20.
doi :
10.1182/blood.V97.1.312 .
PMID
11133776 .
S2CID
10715366 .
El Nemer W, Gane P, Colin Y, et al. (2001).
"Characterization of the laminin binding domains of the Lutheran blood group glycoprotein" . J. Biol. Chem . 276 (26): 23757–62.
doi :
10.1074/jbc.M102978200 .
PMID
11319237 .
Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2003).
"Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo" . J. Biol. Chem . 277 (47): 44864–9.
doi :
10.1074/jbc.M208731200 .
PMID
12244066 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Shin BK, Wang H, Yim AM, et al. (2003).
"Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function" . J. Biol. Chem . 278 (9): 7607–16.
doi :
10.1074/jbc.M210455200 .
PMID
12493773 .
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol . 21 (6): 660–6.
doi :
10.1038/nbt827 .
PMID
12754519 .
S2CID
581283 .
Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system". Transfusion . 43 (12): 1729–37.
doi :
10.1111/j.0041-1132.2003.00600.x .
PMID
14641871 .
S2CID
23121476 .
Zen Q, Batchvarova M, Twyman CA, et al. (2004).
"B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease" . Am. J. Hematol . 75 (2): 63–72.
doi :
10.1002/ajh.10442 .
PMID
14755370 .
S2CID
25313713 .
Kroviarski Y, El Nemer W, Gane P, et al. (2004).
"Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin" . Br. J. Haematol . 126 (2): 255–64.
doi :
10.1111/j.1365-2141.2004.05010.x .
PMID
15238148 .
S2CID
27161744 .
Drewniok C, Wienrich BG, Schön M, et al. (2005). "Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer". Arch. Dermatol. Res . 296 (2): 59–66.
doi :
10.1007/s00403-004-0481-4 .
PMID
15278364 .
S2CID
20724995 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science . 308 (5725): 1149–54.
Bibcode :
2005Sci...308.1149C .
doi :
10.1126/science.1108625 .
PMID
15790807 .
S2CID
13047538 .
Sivakumar S, Lieber S, Librizzi D, et al. (2023).
"Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer" . Clin Transl Med . 13 (1): e1176.
doi :
10.1002/ctm2.1176 .
PMC
9842900 .
PMID
36647260 .
Vainionpää N, Kikkawa Y, Lounatmaa K, et al. (2006). "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells". Am. J. Physiol., Cell Physiol . 290 (3): C764–75.
doi :
10.1152/ajpcell.00285.2005 .
PMID
16236823 .
External links
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This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .