From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Decoy receptor 2 (DCR2 ), also known as TRAIL receptor 4 (TRAILR4 ) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D ), is a human
cell surface receptor of the
TNF-receptor superfamily.
[3]
[4]
[5]
Function
The protein encoded by this gene is a member of the
TNF-receptor superfamily . This receptor contains an
extracellular TRAIL-binding domain, a transmembrane domain, and a truncated
cytoplasmic death domain.
This
receptor does not induce
apoptosis , and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
[5]
References
Further reading
Kimberley FC, Screaton GR (2005).
"Following a TRAIL: update on a ligand and its five receptors" . Cell Res . 14 (5): 359–72.
doi :
10.1038/sj.cr.7290236 .
PMID
15538968 .
Degli-Esposti MA, Dougall WC, Smolak PJ, et al. (1998).
"The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain" . Immunity . 7 (6): 813–20.
doi :
10.1016/S1074-7613(00)80399-4 .
PMID
9430226 .
Phillips TA, Ni J, Pan G, et al. (1999).
"TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege" . J. Immunol . 162 (10): 6053–9.
doi :
10.4049/jimmunol.162.10.6053 .
PMID
10229846 .
Zhang XD, Franco AV, Nguyen T, et al. (2000).
"Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells" . J. Immunol . 164 (8): 3961–70.
doi :
10.4049/jimmunol.164.8.3961 .
PMID
10754286 .
Daigle I, Simon HU (2001).
"Alternative functions for TRAIL receptors in eosinophils and neutrophils" . Swiss Medical Weekly . 131 (17–18): 231–7.
doi :
10.4414/smw.2001.09707 .
PMID
11420819 .
Dörr J, Bechmann I, Waiczies S, et al. (2002).
"Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain" . J. Neurosci . 22 (4): RC209.
doi :
10.1523/JNEUROSCI.22-04-j0001.2002 .
PMC
6757573 .
PMID
11844843 .
Sun SY, Yue P, Chen X, et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells". Cancer Res . 62 (8): 2430–6.
PMID
11956107 .
Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002).
"TRAIL induces death of human oligodendrocytes isolated from adult brain" . Brain . 125 (Pt 11): 2469–80.
doi :
10.1093/brain/awf254 .
PMID
12390973 .
Robertson NM, Zangrilli JG, Steplewski A, et al. (2003).
"Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival" . J. Immunol . 169 (10): 5986–96.
doi :
10.4049/jimmunol.169.10.5986 .
PMID
12421985 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ou D, Metzger DL, Wang X, et al. (2003).
"TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction" . Diabetologia . 45 (12): 1678–88.
doi :
10.1007/s00125-002-0926-2 .
PMID
12488957 .
Hasel C, Dürr S, Rau B, et al. (2003).
"In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas" . Lab. Invest . 83 (6): 825–36.
doi :
10.1097/01.lab.0000073126.56932.46 .
PMID
12808117 .
Kotelkin A, Prikhod'ko EA, Cohen JI, et al. (2003).
"Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand" . J. Virol . 77 (17): 9156–72.
doi :
10.1128/JVI.77.17.9156-9172.2003 .
PMC
187410 .
PMID
12915532 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Shivapurkar N, Toyooka S, Toyooka KO, et al. (2004).
"Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types" . Int. J. Cancer . 109 (5): 786–92.
doi :
10.1002/ijc.20041 .
PMID
14999791 .
S2CID
10876221 .
Zhang Z, Henzel WJ (2005).
"Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24.
doi :
10.1110/ps.04682504 .
PMC
2286551 .
PMID
15340161 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others