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Professor of Bioinformatics
Christine Anne Orengo
FRS is a
Professor of
Bioinformatics at
University College London (UCL)
[2]
[6]
[7]
[8] known for her work on
protein structure , particularly the
CATH database .
[5]
[9] Orengo serves as
president of the
International Society for Computational Biology (ISCB), the first woman to do so in the history of the society.
[10]
Education
Orengo studied
Chemical Physics at the
University of Bristol where she was awarded a
Bachelor of Science degree in 1976.
[11] She continued her studies at the
University of Aberdeen where she was awarded a
Master of Science degree in
Medical Physics in 1977 for research on the disruption of
iron metabolism in
laboratory rats with
Yoshida
sarcomas .
[12] She was awarded a
PhD for research on the
redox properties of
haem in
proteins in 1984 from UCL.
[13]
Career and research
Following her PhD, Orengo worked in industry as Chief Chemist for FCI International, Brussels and mathematical modeller for Humphreys & Glasgow in London.
[11] In 1987 she was appointed a
postdoctoral researcher at the
National Institute for Medical Research (NIMR) in
Mill Hill where she worked until 1990.
[9] She joined the department of
biochemistry and
molecular biology at UCL and in 1995 and was awarded a
Medical Research Council (MRC) senior
fellowship in Bioinformatics. She was promoted to Professor of Bioinformatics in 2002.
[9]
Orengo's research analyses genes, proteins and biological systems using
computational methods to
classify proteins into evolutionary families . Her research has been funded by the Medical Research Council and the
Biotechnology and Biological Sciences Research Council (BBSRC).
[14]
Orengo is co-editor with
David Jones and
Janet Thornton of the textbook Bioinformatics: Genes, Proteins and Computers .
[15] As of 2021
[update] , according to
Google Scholar
[2] and
Scopus
[6] her most cited work has been published in
Nature ,
[16]
Nucleic Acids Research ,
[17]
[18]
Structure
[5] and the
Journal of Molecular Biology .
[19]
[20] Her former doctoral students include
Camilla Pang ,
[3] Sonja Lehtinen
[21]
[22] and Ian Sillitoe.
[23]
Awards and honours
Orengo was elected a member of the
European Molecular Biology Organization (EMBO) in 2014 and a
Fellow of the Royal Society (FRS) in 2019.
[1]
[24]
[25]
References
^
a
b Anon (2015).
"The EMBO Pocket Directory" (PDF) . Heidelberg: European Molecular Biology Organization. Archived from
the original (PDF) on 16 March 2015.
^
a
b
c
Christine Orengo publications indexed by
Google Scholar
^
a
b Pang, Camilla Sih Mai (2018).
Developing a computational approach to investigate the impacts of disease-causing mutations on protein function . ucl.ac.uk (PhD thesis). University College London.
OCLC
1063745930 .
EThOS
uk.bl.ethos.747644 .
^
Christine Orengo at
Library of Congress
^
a
b
c Orengo, C. A.; Michie, A. D.; Jones, S.; Jones, D. T.; Swindells, M. B.;
Thornton, J. M. (1997).
"CATH – a hierarchic classification of protein domain structures" . Structure . 5 (8): 1093–1109.
doi :
10.1016/S0969-2126(97)00260-8 .
PMID
9309224 .
^
a
b
Christine Orengo publications indexed by the
Scopus bibliographic database. (subscription required)
^
Christine Orengo publications from
Europe PubMed Central
^ Christine Orengo's
ORCID
0000-0002-7141-8936
^
a
b
c
"Professor Christine Orengo" . University College London. Archived from
the original on 19 May 2015.
^
"Officers and Directors" . Iscb.org. Retrieved 29 February 2020 .
^
a
b
"GeCIP Detailed Research Plan Form" (PDF) . Genomics England . Retrieved 27 April 2021 .
^ Orengo, Christine Anne (1977). Disruption of iron metabolism in rats with Yoshida sarcomas (MSc thesis). University of Aberdeen.
OCLC
646442339 .
^ Orengo, Christine Anne (1984).
A study of the redox properties of haem in proteins and model systems . london.ac.uk (PhD thesis). University College London.
OCLC
927065626 .
^
"UK Government research grants awarded to Christine Orengo" .
Research Councils UK . 27 November 2015. Archived from
the original on 27 November 2015.
^ Bioinformatics: Genes, Proteins and Computers . BIOS. 2003.
ISBN
1859960545 .
^ Orengo, Christine Anne; Jones, David T.; Thornton, Janet M. (1994). "Protein superfamilles and domain superfolds". Nature . 372 (6507): 631–634.
Bibcode :
1994Natur.372..631O .
doi :
10.1038/372631a0 .
ISSN
0028-0836 .
PMID
7990952 .
S2CID
4330359 .
^ Hunter, S.;
Apweiler, R. ;
Attwood, T. ;
Bairoch, A. ;
Bateman, A. ; Binns, D.;
Bork, P. ; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.;
Gough, J. ; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Laugraud, A.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J.; Mistry, J.; Mitchell, A.; Mulder, N.; Natale, D.; Orengo, C.; Quinn, A. F. (January 2009).
"InterPro: the integrative protein signature database" .
Nucleic Acids Research . 37 (Database issue): D211–D215.
doi :
10.1093/nar/gkn785 .
ISSN
0305-1048 .
PMC
2686546 .
PMID
18940856 .
^ Hunter, S.; Jones, P.; Mitchell, A.; Apweiler, R.; Attwood, T. K.; Bateman, A.; Bernard, T.; Binns, D.; Bork, P.; Burge, S.; De Castro, E.; Coggill, P.; Corbett, M.; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.; Fraser, M.; Gough, J.; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J. (2011).
"InterPro in 2011: New developments in the family and domain prediction database" . Nucleic Acids Research . 40 (Database issue): D306–D312.
doi :
10.1093/nar/gkr948 .
PMC
3245097 .
PMID
22096229 .
^ Todd, Annabel E; Orengo, Christine A; Thornton, Janet M (2001).
"Evolution of function in protein superfamilies, from a structural perspective" . Journal of Molecular Biology . 307 (4): 1113–1143.
doi :
10.1006/jmbi.2001.4513 .
ISSN
0022-2836 .
PMID
11286560 .
S2CID
14355820 .
^ Taylor, William R.; Orengo, Christine Anne (1989). "Protein structure alignment". Journal of Molecular Biology . 208 (1): 1–22.
doi :
10.1016/0022-2836(89)90084-3 .
ISSN
0022-2836 .
PMID
2769748 .
^ Lehtinen, Sonja; Bähler, Jürg; Orengo, Christine (2015).
"Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations" . Scientific Reports . 5 : 16726.
Bibcode :
2015NatSR...516726L .
doi :
10.1038/srep16726 .
ISSN
2045-2322 .
PMC
4644955 .
PMID
26568486 .
^
"Orengo lab alumni" . University College London. 22 May 2015. Archived from
the original on 22 May 2015.
^ Sillitoe, Ian (2003).
Consensus templates for protein structure recognition . london.ac.uk (PhD thesis). University College London.
OCLC
500146824 .
EThOS
404942 .
^
"EMBO member: Christine Anne Orengo" . Heidelberg: EMBO. Archived from
the original on 6 December 2015.
^ Anon (2019).
"Professor Christine Orengo FRS" . royalsociety.org . London. Archived from
the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where: “All text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License .” --
Royal Society Terms, conditions and policies at the
Wayback Machine (archived 2016-11-11)
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