From Wikipedia, the free encyclopedia
American professor at Harvard University
Sean Roberts Eddy is Professor of Molecular & Cellular Biology and of Applied Mathematics at
Harvard University. Previously he was based at the
Janelia Research Campus from 2006 to 2015
[1]
[7]
[8] in
Virginia. His research interests are in
bioinformatics,
computational biology and
biological sequence analysis.
[9]
[10]
[11]
[12] As of 2016
[update] projects include the use of
Hidden Markov models
[13]
[14] in
HMMER, Infernal
[15]
Pfam and
Rfam.
[16]
[17]
[18]
[19]
Education
Eddy graduated June, 1982 from Marion Center Area High School,
Marion Center, Pennsylvania. He then completed a
Bachelor of Science in Biology at
California Institute of Technology in 1986,
[20] followed by a
Doctor of Philosophy in
molecular biology at the
University of Colorado under the supervision of Larry Gold in 1991 studying the
T4 phage.
[2]
[21]
[22]
Career
From 1992 to 1995 he was a
postdoctoral
research fellow at the
Medical Research Council (MRC)
Laboratory of Molecular Biology (LMB) in Cambridge UK working with
John Sulston and
Richard Durbin. From 1995 to 2007 he worked at
Washington University School of Medicine and has been working for the Howard Hughes Medical Institute since 2000.
Awards and honours
In 2007, Sean was the winner of the
Benjamin Franklin Award in Bioinformatics for contributions to
Open Access in the Life Sciences.
[23]
In 2022, Eddy was elected as a
Fellow of the
International Society for Computational Biology.
[24]
References
- ^
a
b
Sean Eddy publications indexed by
Google Scholar
- ^
a
b Eddy, Sean Roberts (1991). Introns in the T-even bacteriophages (PhD thesis). University of Colorado.
OCLC
28253022.
ProQuest
303935681.
-
^ Finn, R. D.; Clements, J.;
Eddy, S. R. (2011).
"HMMER web server: Interactive sequence similarity searching". Nucleic Acids Research. 39 (Web Server issue): W29–W37.
doi:
10.1093/nar/gkr367.
PMC
3125773.
PMID
21593126.
-
^ Nawrocki, E. P.; Kolbe, D. L.;
Eddy, S. R. (2009).
"Infernal 1.0: Inference of RNA alignments".
Bioinformatics. 25 (10): 1335–1337.
doi:
10.1093/bioinformatics/btp157.
PMC
2732312.
PMID
19307242.
-
^
Bateman, A.; Coin, L.;
Durbin, R.; Finn, R. D.; Hollich, V.; Griffiths-Jones, S.; Khanna, A.; Marshall, M.; Moxon, S.; Sonnhammer, E. L.; Studholme, D. J.; Yeats, C.;
Eddy, S. R. (2004).
"The Pfam protein families database".
Nucleic Acids Research. 32 (Database issue): 138D–1141.
doi:
10.1093/nar/gkh121.
ISSN
0305-1048.
PMC
308855.
PMID
14681378.
-
^ Gardner, P. P.; Daub, J.; Tate, J.; Moore, B. L.; Osuch, I. H.; Griffiths-Jones, S.; Finn, R. D.; Nawrocki, E. P.; Kolbe, D. L.;
Eddy, S. R.;
Bateman, A. (2010).
"Rfam: Wikipedia, clans and the "decimal" release".
Nucleic Acids Research. 39 (Database issue): D141–D145.
doi:
10.1093/nar/gkq1129.
PMC
3013711.
PMID
21062808.
-
^ Anon (2012).
"HHMI Scientist Bio: Sean R. Eddy, Ph.D." Archived from
the original on 2012-06-16.
-
^ Kaplan, Karen (2011).
"A roll of the dice: Sean Eddy has his dream job".
Nature. 479 (7373): 433–435.
doi:
10.1038/nj7373-433a.
PMID
22106470.
-
^
Durbin, Richard M.;
Eddy, Sean R.;
Krogh, Anders; Mitchison, Graeme (1998),
Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids (1st ed.), Cambridge, New York:
Cambridge University Press,
ISBN
0-521-62971-3,
OCLC
593254083
-
^ Rivas, E.; Lang, R.;
Eddy, S. R. (2011).
"A range of complex probabilistic models for RNA secondary structure prediction that includes the nearest-neighbor model and more". RNA. 18 (2): 193–212.
doi:
10.1261/rna.030049.111.
PMC
3264907.
PMID
22194308.
-
^
Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (Feb 2001).
"Initial sequencing and analysis of the human genome" (PDF). Nature. 409 (6822): 860–921.
Bibcode:
2001Natur.409..860L.
doi:
10.1038/35057062.
ISSN
0028-0836.
PMID
11237011.
-
^
"Sean Eddy's homepage". selab.janelia.org. Archived from
the original on 2010-12-04.
-
^
Eddy, S. R. (2004).
"What is a hidden Markov model?".
Nature Biotechnology. 22 (10): 1315–1316.
doi:
10.1038/nbt1004-1315.
PMID
15470472.
-
^
Eddy, S. (1998).
"Profile hidden Markov models". Bioinformatics. 14 (9): 755–763.
doi:
10.1093/bioinformatics/14.9.755.
PMID
9918945.
-
^
"Sean Eddy's blog". cryptogenomicon.org.
-
^
Eddy, S. R. (2012).
"The C-value paradox, junk DNA and ENCODE". Current Biology. 22 (21): R898–R899.
doi:
10.1016/j.cub.2012.10.002.
PMID
23137679.
-
^
Sean Eddy's publications indexed by the
Scopus bibliographic database. (subscription required)
-
^
Reading Genomes Bit by Bit - Sean Eddy on
YouTube, GenomeTV
-
^
Sean Eddy Keynote OBF BOSC on
YouTube, 2013-07-20
-
^
"Sean Eddy CV" (PDF). selab.janelia.org. Archived from
the original (PDF) on 2012-03-09.
-
^
Eddy, S. R.; Gold, L. (1991).
"The phage T4 nrdB intron: A deletion mutant of a version found in the wild". Genes & Development. 5 (6): 1032–1041.
doi:
10.1101/gad.5.6.1032.
PMID
2044951.
-
^ Tuerk, C.;
Eddy, S.; Parma, D.; Gold, L. (1990). "Autogenous translational operator recognized by bacteriophage T4 DNA polymerase".
Journal of Molecular Biology. 213 (4): 749–761.
doi:
10.1016/S0022-2836(05)80261-X.
PMID
2359122.
-
^ Anon (2007).
"BioMed Central Blog: Sean Eddy wins open access award". blogs.openaccesscentral.com. Archived from
the original on 2011-06-07.
-
^
"April 28, 2022: ISCB Congratulates and Introduces the 2022 Class of Fellows!". www.iscb.org. Retrieved 17 June 2022.
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