German bioinformatician
Sarah Amalia Teichmann (born 15 April 1975)
[11]
FRS
FMedSci
[15] is a German scientist who is head of
cellular genetics at the
Wellcome Sanger Institute
[16] and a visiting research group leader at the
European Bioinformatics Institute (EMBL-EBI).
[17]
[8] She serves as director of research (equivalent to Professor)
[18] in the
Cavendish Laboratory ,
[19] at the
University of Cambridge and a senior
research fellow at
Churchill College, Cambridge .
[20]
[21]
Education
Teichmann was educated at the
European School, Karlsruhe in Germany from 1981 to 1993 where she completed the
European Baccalaureate in 1993.
[22] Teichmann went on to study the
Natural Sciences Tripos at
Trinity College, Cambridge and was awarded a
first class
Bachelor of Arts degree in 1996. In 1999, she completed her
PhD supervised by
Cyrus Chothia
[23] at the
Laboratory of Molecular Biology (LMB) on
genome evolution .
[24]
Career and research
Following her PhD, Teichmann did
postdoctoral research supervised by
Janet Thornton at University College London
[17] and funded by the
Beit Memorial Fellowships for Medical Research . From 2001-2012, she was a
Medical Research Council (MRC) Programme Leader, studying patterns in
protein interactions and
transcriptional regulatory networks .
[25]
[26]
In 2013 Teichmann was appointed a joint position at the
Wellcome Trust Sanger Institute and the
European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she served as a
teaching fellow and director of studies at
Trinity College, Cambridge . Since 2016 Teichmann has served as the head of Cellular Genetics at the
Wellcome Trust Sanger Institute
[16] and a visiting research group leader at the EBI.
[8]
Teichmann's research
[27]
[28]
[29]
[30] investigates
gene expression
[31]
[32]
[33] and
protein complex assembly
[34] using both
wet laboratory and
computational biology techniques.
[35] In particular her research group:
...seeks to elucidate the principles of protein structure evolution, higher order
protein structure and
protein folding , and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding
gene expression regulation, and in our wetlab at the Sanger Institute use mouse
T helper cells as a model of
cell differentiation .
[36]
Teichmann's research has been funded by the
European Research Council (ERC), the
Medical Research Council (MRC), the
Biotechnology and Biological Sciences Research Council (BBSRC),
[37] the
Wellcome Trust , the
European Molecular Biology Organization (EMBO), the
Framework Programmes for Research and Technological Development and the
European Cooperation in Science and Technology (COST) .
[22]
As of 2015
[update] Teichmann has supervised several PhD students to completion
[38]
[22] including
Madan Babu ,
[10] Varodom Charoensawan
[39] Subhajyoti De
[40] Jay Han,
[41] Sarah Kay Kummerfeld
[42]
[43] Tina Perica,
[44] and Jing Su,
[45] and several
postdoctoral researchers who have gone on to become
Principal investigators (PIs).
[22]
[46]
[47]
[48]
Awards and honours
Teichmann has won a number of awards. In 2010, she was awarded the
Colworth Medal from the
Biochemical Society .
[49]
[50] In 2012, Teichman was awarded the
Francis Crick Medal and Lecture , membership of the
European Molecular Biology Organization (EMBO)
[3] and the Lister Prize from the
Lister Institute of Preventive Medicine .
[2] In 2015 she was awarded the
Michael and Kate Bárány Award for young investigators by the
Biophysical Society
[51] and the
EMBO Gold Medal . Teichmann was elected a
Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads:
Sarah Teichmann is Research Group Leader at
EMBL -European Bioinformatics Institute and has made major contributions to biology over the past 15 years. A fundamental discovery was her work to define key biophysical mechanisms in protein complex assembly, showing that protein complexes assemble via distinct, ordered pathways. She showed that these assembly pathways are conserved in evolution and how they may be predicted from 3D structure. Her databases and computational analysis methods have had a broad and deep impact on the community. She represents a new breed of scientists at the interface between computational and experimental molecular biology.
[15]
Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.
[52] She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research.[
citation needed ] Teichmann was elected an
ISCB Fellow in 2016 by the
International Society for Computational Biology .
[6]
In 2020, Teichmann was recognised on The Times 'Science Power List' for her work on the
Human Cell Atlas
[53] and elected a
Fellow of the Royal Society .
[54] She won the
Suffrage Science award in 2012.
[49]
In 2023 Teichmann was the winner of the
Federation of European Biochemical Societies (FEBS) EMBO Women in Science Award.
[55]
Personal life
Teichmann has two daughters.
[12]
[14] Teichmann is the co-author of the children's language education novel Teenage Detectives ,
[56] which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in
Karlsruhe .
[57]
References
^ Perica, Tina; Marsh, Joseph A.; Sousa, Filipa L.; Natan, Eviatar; Colwell, Lucy J.; Ahnert, Sebastian E.; Teichmann, Sarah A. (2012). "The emergence of protein complexes: quaternary structure, dynamics and allostery". Biochemical Society Transactions . 40 (3): 475–491.
doi :
10.1042/BST20120056 .
PMID
22616857 .
S2CID
21452774 .
^
a
b
"Dr Sarah Teichmann, EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute" . lister-institute.org.uk . Archived from
the original on 15 October 2014.
^
a
b
"Sarah A. Teichmann EBI, Cambridge (Hinxton), United Kingdom EMBO 2012" . European Molecular Biology Organization. Archived from
the original on 19 January 2016.
^
"Finding patterns in genes and proteins: decoding the logic of molecular interactions" .
Royal Society . 2012. Archived from
the original on 10 November 2012.
^
Finding patterns in genes and proteins: decoding the logic of molecular interactions on
YouTube ,
Royal Society
^
a
b Anon (2017).
"ISCB Fellows" . iscb.org .
International Society for Computational Biology . Archived from
the original on 20 March 2017.
^
Sarah Teichmann publications indexed by
Google Scholar
^
a
b
c
"People & Groups: Sarah Teichmann, Group Leader - Teichmann research group" . EMBL-EBI. 2013. Archived from
the original on 3 April 2013.
^ Park, J;
Teichmann, S. A. ;
Hubbard, T ;
Chothia, C (1997). "Intermediate sequences increase the detection of homology between sequences". Journal of Molecular Biology . 273 (1): 349–54.
doi :
10.1006/jmbi.1997.1288 .
PMID
9367767 .
S2CID
28606158 .
^
a
b Mohan, Madan Babu (2004).
Evolution of transcriptional regulatory networks . jisc.ac.uk (PhD thesis). University of Cambridge.
OCLC
890159758 .
EThOS
uk.bl.ethos.616113 .
^
a
b
c Teichmann, Sarah (2007).
"Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV" (PDF) . mrc-lmb.cam.ac.uk . Laboratory of Molecular Biology. Archived from
the original (PDF) on 26 February 2013.
^
a
b Greenstreet, Rosanna (2018).
"Sarah Teichmann: 'I wake as early as 4am and think about work' " .
The Guardian . London.
^ Marx, Vivien (2014).
"The Author File: Janet Thornton" .
Nature Methods . 11 (2): 115.
doi :
10.1038/nmeth.2831 .
PMID
24645189 .
S2CID
1970327 .
^
a
b Pain, Elisabeth (2015). "Harnessing computer power to understand biology". Science .
doi :
10.1126/science.caredit.a1500172 .
^
a
b Anon (2015).
"Dr Sarah Teichmann FMedSci" . acmedsci.ac.uk . London:
Academy of Medical Sciences . Archived from
the original on 6 July 2015.
^
a
b
"Dr Sarah Teichmann, FMedSci, Head of Cellular Genetics" . Cambridge: sanger.ac.uk. Archived from
the original on 15 April 2016.
^
a
b Marx, Vivien (2016).
"The Author File: Sarah Teichmann" . Nature Methods . 13 (4): 279.
doi :
10.1038/nmeth.3808 .
ISSN
1548-7091 .
PMID
27203785 .
S2CID
205424792 .
^ Anon (2013).
"Job titles and duties at the University of Cambridge" . University of Cambridge. Archived from
the original on 3 July 2013.
^ Anon (2015).
"Dr Sarah Teichmann FMedSci" . tcm.phy.cam.ac.uk . Cambridge. Archived from
the original on 12 September 2015.
^
"People – Churchill College" . www.chu.cam.ac.uk .
^ Dhillon, Paraminder; Teichmann, Sarah A. (2019).
"In conversation with Sarah Teichmann" .
The FEBS Journal . 286 (8): 1445–1450.
doi :
10.1111/febs.14806 .
ISSN
1742-464X .
PMID
31012289 .
^
a
b
c
d Anon (2015).
"Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany" . Federation of European Biochemical Societies. Archived from
the original on 20 February 2015.
^
Chothia, C ;
Gough, J ; Vogel, C;
Teichmann, S. A. (2003). "Evolution of the protein repertoire". Science . 300 (5626): 1701–3.
Bibcode :
2003Sci...300.1701C .
doi :
10.1126/science.1085371 .
PMID
12805536 .
S2CID
27681885 .
^ Teichmann, Sarah Amalia (1999).
Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge.
OCLC
894602472 .
EThOS
uk.bl.ethos.624585 .
^ Babu, M. M.; Luscombe, N. M.; Aravind, L;
Gerstein, M ;
Teichmann, S. A. (2004). "Structure and evolution of transcriptional regulatory networks".
Current Opinion in Structural Biology . 14 (3): 283–91.
CiteSeerX
10.1.1.471.9692 .
doi :
10.1016/j.sbi.2004.05.004 .
PMID
15193307 .
^ Luscombe, N. M.; Babu, M. M.; Yu, H; Snyder, M;
Teichmann, S. A. ;
Gerstein, M (2004). "Genomic analysis of regulatory network dynamics reveals large topological changes".
Nature . 431 (7006): 308–12.
Bibcode :
2004Natur.431..308L .
doi :
10.1038/nature02782 .
PMID
15372033 .
S2CID
4391278 .
^
Sarah A. Teichmann author profile page at the
ACM Digital Library
^
Sarah Teichmann at
DBLP Bibliography Server
^
Sarah Teichmann publications indexed by the
Scopus bibliographic database. (subscription required)
^
Sarah Teichmann publications from
Europe PubMed Central
^ Carninci, P; Kasukawa, T; Katayama, S;
Gough, J ; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.;
Brenner, S. E. ; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A;
Apweiler, R ; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T; et al. (2005). "The transcriptional landscape of the mammalian genome". Science . 309 (5740): 1559–63.
Bibcode :
2005Sci...309.1559F .
doi :
10.1126/science.1112014 .
PMID
16141072 .
S2CID
8712839 .
^ Drosophila 12 Genomes, Consortium; Clark, A. G.;
Eisen, M. B. ; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007).
"Evolution of genes and genomes on the Drosophila phylogeny" . Nature . 450 (7167): 203–18.
Bibcode :
2007Natur.450..203C .
doi :
10.1038/nature06341 .
PMID
17994087 . {{
cite journal }}
: CS1 maint: numeric names: authors list (
link )
^ Wilson, D; Charoensawan, V; Kummerfeld, S. K.; Teichmann, S. A. (2008).
"DBD--taxonomically broad transcription factor predictions: New content and functionality" . Nucleic Acids Research . 36 (Database issue): D88–92.
doi :
10.1093/nar/gkm964 .
PMC
2238844 .
PMID
18073188 .
^ Levy, E. D.; Teichmann, S (2013). "Structural, Evolutionary, and Assembly Principles of Protein Oligomerization". Oligomerization in Health and Disease . Progress in Molecular Biology and Translational Science. Vol. 117. pp. 25–51.
doi :
10.1016/B978-0-12-386931-9.00002-7 .
ISBN
9780123869319 .
PMID
23663964 .
^ Perica, T; Kondo, Y; Tiwari, S. P.; McLaughlin, S. H.; Kemplen, K. R.; Zhang, X; Steward, A; Reuter, N;
Clarke, J ;
Teichmann, S. A. (2014).
"Evolution of oligomeric state through allosteric pathways that mimic ligand binding" . Science . 346 (6216): 1254346.
doi :
10.1126/science.1254346 .
PMC
4337988 .
PMID
25525255 .
^
"Teichmann group Research EMBL-EBI" . European Bioinformatics Institute. 2013. Archived from
the original on 2 April 2013.
^ Anon (2015).
"UK Government research grants awarded to Sarah Teichmann" .
Research Councils UK . Archived from
the original on 3 March 2015.
^ Teichmann, Sarah (2015).
"Alumni from Sarah Teichmann's Group" . European Bioinformatics Institute. Archived from
the original on 27 May 2024.
^ Charoensawan, Varodom (2011).
Evolution and dynamics of transcription factors and gene expression patterns . ethos.bl.uk (PhD thesis). University of Cambridge.
OCLC
890150091 .
^ De, Subhajyoti (2008).
Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood . ethos.bl.uk (PhD thesis). University of Cambridge.
OCLC
890154864 .
^ Han, Jay (2007).
Structure, function and evolution of protein-protein interactions (PhD thesis). University of Cambridge.
^ Kummerfeld, Sarah Kay (2006).
Towards understanding the protein universe : genome-scale studies of evolution and gene regulation . ethos.bl.uk (PhD thesis). University of Cambridge.
^ Levy, Emmanuel Doram (2008).
Classification, evolution, and assembly of protein complexes . ethos.bl.uk (PhD thesis). University of Cambridge.
^ Perica, Tina (2013).
Evolutionary and structural dynamics of protein complexes (PhD thesis). University of Cambridge.
OCLC
890148231 .
^ Su, Jing (2012).
Computational prediction of regulatory elements (PhD thesis). University of Cambridge.
^ Adryan, B; Teichmann, S. A. (2010).
"The developmental expression dynamics of Drosophila melanogaster transcription factors" .
Genome Biology . 11 (4): R40.
doi :
10.1186/gb-2010-11-4-r40 .
PMC
2884543 .
PMID
20384991 .
^ Gsponer, J; Futschik, M. E.; Teichmann, S. A.; Babu, M. M. (2008).
"Tight regulation of unstructured proteins: From transcript synthesis to protein degradation" .
Science . 322 (5906): 1365–8.
Bibcode :
2008Sci...322.1365G .
doi :
10.1126/science.1163581 .
PMC
2803065 .
PMID
19039133 .
^ Hebenstreit, D; Gu, M; Haider, S; Turner, D. J.; Liò, P; Teichmann, S. A. (2011).
"EpiChIP: Gene-by-gene quantification of epigenetic modification levels" .
Nucleic Acids Research . 39 (5): e27.
doi :
10.1093/nar/gkq1226 .
PMC
3061070 .
PMID
21131282 .
^
a
b Anon (2012).
"Honour and heirloom for Sarah Teichmann" . Laboratory of Molecular Biology. Archived from
the original on 3 March 2015.
^ Anon (2015).
"Women at Cambridge: Sarah Amalia Teichmann" . University of Cambridge. Archived from
the original on 20 February 2015.
^
"Biophysical Society Names 2015 Award Recipients" (PDF) . Biophysical Society. Archived from
the original (PDF) on 4 October 2014. Retrieved 8 March 2015 .
^ Gaskell & Kostic (2015).
"The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist" . Cell . Archived from
the original on 2 April 2016. Retrieved 25 November 2015 .
^ Franklin-Wallis, Oliver (23 May 2020).
"From pandemics to cancer: the science power list" . The Times .
ISSN
0140-0460 . Retrieved 26 May 2020 .
^
"Sarah Teichmann" . Royal Society. Retrieved 20 September 2020 .
^
"FEBS | EMBO Women in Science Award - FEBS" . 26 August 2022. Retrieved 4 January 2024 .
^ Teichmann, Sarah; Teichmann, Virginia (1991). Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities . Germany: Cornelsen Verlag.
ISBN
978-3464053362 .
^ Anon.
"The Honeycomb: Dr. Virginia Teichmann: Word Lover" (PDF) . expat-karlsruhe.com . Retrieved 7 December 2015 .
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