From Wikipedia, the free encyclopedia
Desmond Gerard Higgins is a
Professor of
Bioinformatics at
University College Dublin ,
[3]
[12]
[13]
[14] widely known for
CLUSTAL ,
[15] a series of computer programs for performing
multiple sequence alignment . According to
Nature , Higgins' papers describing CLUSTAL
[10]
[11] are among the top ten most highly cited
scientific papers of all time.
[16]
[17]
[18]
Education
Higgins was educated at
Trinity College, Dublin
[19] where he was awarded a
PhD in 1988 for research on
numerical taxonomy of
Pterygote insects .
[20]
Research
Research in the Higgins laboratory
[3] focuses on developing new bioinformatics and statistical tools for
evolutionary biology . The
CLUSTAL program for
multiple sequence alignment has been developed in the Higgins lab and the
T-Coffee software was initially developed in the lab with by Cedric Notredame.
Multivariate statistics are used to analyse
microarray data sets and
molecular evolution such as the evolution of
promoters ,
introns and
non-coding RNA .
[12]
[19]
Awards and honours
Higgins was elected a
Fellow of the
International Society for Computational Biology (ISCB) in 2015.
[1] He was awarded the Kimura Motoo Award in 2016 for his contributions to the advancement of evolutionary biology and molecular phylogeny.
[21] In 2018, Higgins received the
Benjamin Franklin Award for open access in the life sciences.
[2] In March 2023, Higgins was awarded the Lennart Philipson Award in recognition of his major contributions towards enabling bioinformatics technologies based on multiple sequence alignment.
[22]
References
^
a
b
"ISCB Fellows" . International Society for Computational Biology. Archived from
the original on 15 April 2015.
^
a
b
"Benjamin Franklin Award - Bioinformatics.org" . www.bioinformatics.org . Retrieved 16 March 2018 .
^
a
b
c
Desmond G. Higgins publications indexed by
Google Scholar
^
a
b Notredame, C. D.; Higgins, D. G.; Heringa, J. (2000). "T-coffee: A novel method for fast and accurate multiple sequence alignment". Journal of Molecular Biology . 302 (1): 205–17.
doi :
10.1006/jmbi.2000.4042 .
PMID
10964570 .
S2CID
10189971 .
^
"Des Higgins, PhD: Computational Biology Tree" . academictree.org . Archived from
the original on 14 July 2017.
^ Sharp, Paul M.; Cowe, Elizabeth;
Higgins, Desmond G. ; Shields, Denis C.;
Wolfe, Kenneth H. ; Wright, Frank (1988).
"Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity" .
Nucleic Acids Research . 16 (17): 8207–8211.
doi :
10.1093/nar/16.17.8207 .
ISSN
0305-1048 .
PMC
338553 .
PMID
3138659 .
^
Des Higgins at
Library of Congress
^ Higgins, Desmond G.;
Sharp, Paul M. (1988). "CLUSTAL: a package for performing multiple sequence alignment on a microcomputer". Gene . 73 (1): 237–244.
doi :
10.1016/0378-1119(88)90330-7 .
PMID
3243435 .
^ Higgins, Desmond G.;
Sharp, Paul M. (1989). "Fast and sensitive multiple sequence alignments on a microcomputer". Bioinformatics . 5 (2): 151–153.
doi :
10.1093/bioinformatics/5.2.151 .
PMID
2720464 .
^
a
b Thompson, J. D.; Gibson, T. J.; Plewniak, F.; Jeanmougin, F.; Higgins, D. G. (1997).
"The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools" . Nucleic Acids Research . 25 (24): 4876–4882.
doi :
10.1093/nar/25.24.4876 .
PMC
147148 .
PMID
9396791 .
^
a
b Thompson, J. D.; Higgins, D. G.; Gibson, T. J. (1994).
"CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice" . Nucleic Acids Research . 22 (22): 4673–4680.
doi :
10.1093/nar/22.22.4673 .
PMC
308517 .
PMID
7984417 .
^
a
b
"Professor Desmond Gerard Higgins B.A.(Mod), PhD" . Dublin: University College Dubin. Archived from
the original on 5 April 2015.
^
"Des Higgins laboratory" . University College Dublin. Archived from
the original on 14 December 2014.
^
Desmond G. Higgins publications from
Europe PubMed Central
^
Des Higgins: Visualizing Multiple Sequence Alignments on
YouTube , Broad Institute
^ Van Noorden, R.; Maher, B.;
Nuzzo, R. (2014).
"The top 100 papers: Nature explores the most-cited research of all time" .
Nature . 514 (7524): 550–3.
doi :
10.1038/514550a .
PMID
25355343 .
^ Gorey, Colm (2014).
"Irish professor Des Higgins in top 10 most cited papers of all time" . Dublin: siliconrepublic.com. Archived from
the original on 5 June 2015.
^
Desmond G. Higgins publications indexed by the
Scopus bibliographic database. (subscription required)
^
a
b Des Higgins
ORCID
0000-0002-3952-3285
^ Higgins, Des (1981). A numerical taxonomy of Pterygote insects (PhD thesis). Trinity College, Dublin.
OCLC
842505334 .
ProQuest
301410442 .
^
"Prof Des Higgins to Receive Kimura Motoo Award" . UCD School of Medicine . Retrieved 31 May 2021 .
^
"EMBL Alumni Awards Announced for 2023" . EMBL Alumni Awards . 29 March 2023. Retrieved 31 March 2023 .
2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
International National Academics Other