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Chemical compound
AR-231,453
N -(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
CAS Number
PubChem
CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (
EPA )
Formula C 21 H 24 F N 7 O 5 S
Molar mass 505.53 g·mol−1 3D model (
JSmol )
Fc2cc(S(=O)(C)=O)ccc2Nc1ncnc(c1N(=O)=O)N(CC3)CCC3c(n4)onc4C(C)C
InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
Y Key:DGBKNTVAKIFYNU-UHFFFAOYSA-N
Y
N Y
(what is this?)
(verify)
AR-231,453 is an
agonist for the suggested novel
cannabinoid receptor
GPR119 .
[1]
See also
References
^ Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM (2008). "Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119". J Med Chem . 51 (17): 5172–5175.
doi :
10.1021/jm8006867 .
PMID
18698756 .
Phytocannabinoids (
comparison )
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Classical cannabinoids (dibenzopyrans) Non-classical cannabinoids Adamantoylindoles Benzimidazoles Benzoylindoles Cyclohexylphenols
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Naphthoylindoles Naphthoylpyrroles Naphthylmethylindenes Naphthylmethylindoles Phenylacetylindoles Pyrazolecarboxamides Pyrrolobenzoxazines Quinolinyl esters Tetramethylcyclo- propanoylindazoles Tetramethylcyclo- propanoylindoles Tetramethylcyclo- propylindoles Others
Allosteric
CBR Tooltip Cannabinoid receptor
ligands
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Anticannabinoids (antagonists/inverse agonists/antibodies)