From Wikipedia, the free encyclopedia
Chemical compound
Pelubiprofen is a
nonsteroidal anti-inflammatory drug of the
profen class used to treat
back pain and
osteoarthritis.
[1]
Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia,
[2] among other countries.
Research
Pelubiprofen is being studied for use in combination with
eperisone.
[3]
Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied.
[4]
Synthesis
1-(1-piperidino)cyclohexene [2981-10-4] (1)
ethyl 2-(4-formylphenyl)propanoate [43153-04-4] (2)
ethyl 2-(4-(2-oxo-1-cyclohexylidenemethyl)phenyl)propionate, PC54259840 (3)
References
-
^
"Pelubiprofen - Daewon Pharmaceutical". AdisInsight. Springer Nature Switzerland AG.
-
^ Chan-Hyuk K (26 September 2023).
"Daewon Pharm wins $3 million deal to export Pelubi to Indonesia". Korea Biomedial Review.
-
^
"(Eperisone + pelubiprofen) by Daewon Pharmaceutical for Low Back Pain: Likelihood of Approval". pharmaceutical-technology.com. 5 June 2023.
-
^ Park JY, Oh DH, Park SW, Chae BR, Kim CW, Han SH, et al. (May 2021).
"Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption". Pharmaceutics. 13 (5): 745.
doi:
10.3390/pharmaceutics13050745.
PMC
8158122.
PMID
34070062.
-
^ Serradell, MN; Castaer, J.; RS-2131. Drugs Fut 1984, 9, 4, 275.
-
^ Terada, Atsusuke; Naruto, Shunji; Wachi, Kazuyuki; Tanaka, Shigeru; Iizuka, Yoshio; Misaka, Eiichi (1984). "Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds". Journal of Medicinal Chemistry. 27 (2): 212–216. doi:10.1021/jm00368a019.
-
^ Atsusuke Terada, Shigeru Tanaka, & Eiichi Misaka, US4254274 (1981 to Sankyo Co Ltd).
-
^ Yuan Weiguan, et al. CN111153791 (2020 to HUNAN JIUDIAN HONGYANG PHARMACEUTICAL Co.,Ltd).
-
^ Yuan Weiguan, et al. WO2021129651 (to Hunan Jiudian Pharmaceutical Co Ltd).
-
^ Ning Hulin, et al. CN110041191 (2019 to HUNAN JIUDIAN HONGYANG PHARMACEUTICAL Co.,Ltd.).