From Wikipedia, the free encyclopedia
Chemical compound
Gemeprost
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Trade names | Cervagem |
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Other names | methyl (E)-7-[(1R,2S,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyl-oct-1-enyl]-5-oxo-cyclopentyl]hept-2-enoate |
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AHFS/
Drugs.com |
International Drug Names |
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Pregnancy category | |
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Routes of administration |
Pessary |
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ATC code | |
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Legal status |
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AU:
S4 (Prescription only)
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UK:
POM (Prescription only)
[1]
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methyl (2E,11α,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-2,13-dien-1-oate
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CAS Number | |
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PubChem
CID | |
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DrugBank | |
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ChemSpider | |
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UNII | |
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KEGG | |
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CompTox Dashboard (
EPA) | |
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ECHA InfoCard |
100.058.869
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Formula | C23H38O5 |
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Molar mass | 394.552 g·mol−1 |
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3D model (
JSmol) | |
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O=C1C[C@@H](O)[C@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H]1CCCC\C=C\C(=O)OC
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InChI=1S/C23H38O5/c1-5-6-15-23(2,3)21(26)14-13-18-17(19(24)16-20(18)25)11-9-7-8-10-12-22(27)28-4/h10,12-14,17-18,20-21,25-26H,5-9,11,15-16H2,1-4H3/b12-10+,14-13+/t17-,18-,20-,21-/m1/s1 YKey:KYBOHGVERHWSSV-VNIVIJDLSA-N Y
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Gemeprost (16, 16-dimethyl-trans-delta2 PGE1 methyl ester) is an
analogue of
prostaglandin E1.
Clinical use
It is used as a treatment for
obstetric bleeding.[
citation needed]
It is used with
mifepristone to terminate pregnancy up to 24 weeks gestation.
[2]
Side effects
Vaginal bleeding, cramps, nausea, vomiting,
[3] loose stools or diarrhea,
[3] headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild
pyrexia.
[3] Rare: Uterine rupture, severe
hypotension, coronary spasms with subsequent
myocardial infarctions.[
citation needed]
References
External links
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"Gemeprost". Drug Information Portal. U.S. National Library of Medicine.
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Receptor (
ligands) |
DP (D2)Tooltip Prostaglandin D2 receptor |
DP1Tooltip Prostaglandin D2 receptor 1 | |
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DP2Tooltip Prostaglandin D2 receptor 2 | |
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EP (E2)Tooltip Prostaglandin E2 receptor |
EP1Tooltip Prostaglandin EP1 receptor | |
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EP2Tooltip Prostaglandin EP2 receptor | |
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EP3Tooltip Prostaglandin EP3 receptor | |
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EP4Tooltip Prostaglandin EP4 receptor | |
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Unsorted | |
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FP (F2α)Tooltip Prostaglandin F receptor | |
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IP (I2)Tooltip Prostacyclin receptor | |
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TP (TXA2)Tooltip Thromboxane receptor | |
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Unsorted | |
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Enzyme (
inhibitors) |
COX (
PTGS) | |
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PGD2STooltip Prostaglandin D synthase | |
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PGESTooltip Prostaglandin E synthase | |
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PGFSTooltip Prostaglandin F synthase | |
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PGI2STooltip Prostacyclin synthase | |
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TXASTooltip Thromboxane A synthase | |
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Others | |
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