Pynazolam is a
triazolobenzodiazepine derivative first invented in the 1970s,[1] which has in more recent years been sold online as a
designer drug. Anecdotal reports and in silico studies suggest it has relatively potent
hypnotic and
sedative effects.[medical citation needed] Pynazolam is a powerful serotonin releaser similar to
nimetazepam[2] which increases hypnotic activity and euphoria. Anecdotal evidence has also suggested that it's subjective effects are similar to methaqualone[3] although unlike methaqualone, it cannot be smoked due to high melting-point.
Limited pharmacological data is available[4] although their is an increasing availability of the compound for research purposes.[5]
^US 3970664, Sternbach LH, Walser A, "Preparation of triazolo benzodiazepines.", issued 20 July 1976, assigned to Hoffmann-LaRoche, Inc.
^Pranzatelli, Michael R. (1989). "Benzodiazepine-induced shaking behavior in the rat: Structure-activity and relation to serotonin and benzodiazepine receptors". Experimental Neurology. 104 (3): 241–250.
doi:
10.1016/0014-4886(89)90036-8.
^Catalani V, Floresta G, Botha M, Corkery JM, Guirguis A, Vento A, et al. (January 2023). "In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines". Chemical Biology & Drug Design. 101 (1): 40–51.
doi:
10.1111/cbdd.14119.
hdl:2299/25749.
PMID35838189.