39S ribosomal protein L12, mitochondrial is a
protein that in humans is encoded by the MRPL12gene.[4][5][6]
Mammalian
mitochondrial ribosomal proteins are encoded by
nuclear genes and help in
protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%
protein to
rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a
5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by
sequence homology. This gene encodes a 39S subunit protein which forms
homodimers. In prokaryotic ribosomes, two
L7/
L12 dimers and one
L10 protein form the L8 protein complex.[6]
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doi:
10.1021/bi991543s.
PMID10600119.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70.
doi:
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PMID11543634.
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PMID12706105.