40S ribosomal protein S18 is a
protein that in humans is encoded by the RPS18gene.[5][6][7]
Ribosomes, the
organelles that
catalyzeprotein synthesis, consist of a
small 40S subunit and a
large 60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the
cytoplasm. The gene product of the
E. coli ortholog (ribosomal protein S13) is involved in the binding of
fMet-tRNA, and thus, in the initiation of
translation. This gene is an ortholog of
mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome.[7]
Chassin D, Bénifla JL, Delattre C, et al. (1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts". Cancer Res. 54 (19): 5217–23.
PMID7923143.
Kusui K, Sasaki H, Adachi R, et al. (2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem. 262 (1–2): 187–93.
doi:
10.1023/B:MCBI.0000038234.35936.1c.
PMID15532723.
S2CID30534195.