From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Eukaryotic translation initiation factor 4B is a
protein that in humans is encoded by the EIF4B
gene .
[5]
Interactions
eIF4B has been shown to
interact with and stimulate the activity of
eIF4A and bind to the
eIF3 complex through the
eIF3A subunit.
[6] This interaction results in the recruitment of the
eukaryotic small ribosomal subunit (40S) to the mRNA which will in turn set the stage for the later steps leading to
elongation .
See also
References
Further reading
van Heugten HA, Kasperaitis MA, Thomas AA, Voorma HO (1991).
"Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F" . J. Biol. Chem . 266 (11): 7279–84.
doi :
10.1016/S0021-9258(20)89641-0 .
PMID
2016328 .
Milburn SC, Hershey JW, Davies MV, Kelleher K, Kaufman RJ (1990).
"Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif" . EMBO J . 9 (9): 2783–90.
doi :
10.1002/j.1460-2075.1990.tb07466.x .
PMC
551988 .
PMID
2390971 .
Howe JG, Hershey JW (1984).
"Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells" . Cell . 37 (1): 85–93.
doi :
10.1016/0092-8674(84)90303-9 .
PMID
6722878 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Méthot N, Pause A, Hershey JW, Sonenberg N (1994).
"The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence" . Mol. Cell. Biol . 14 (4): 2307–16.
doi :
10.1128/mcb.14.4.2307 .
PMC
358597 .
PMID
8139536 .
Naranda T, Strong WB, Menaya J, Fabbri BJ, Hershey JW (1994).
"Two structural domains of initiation factor eIF-4B are involved in binding to RNA" . J. Biol. Chem . 269 (20): 14465–72.
doi :
10.1016/S0021-9258(17)36646-2 .
PMID
8182051 .
Méthot N, Song MS, Sonenberg N (1996).
"A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3" . Mol. Cell. Biol . 16 (10): 5328–34.
doi :
10.1128/MCB.16.10.5328 .
PMC
231531 .
PMID
8816444 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Richter NJ, Rogers GW, Hensold JO, Merrick WC (1999).
"Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H" . J. Biol. Chem . 274 (50): 35415–24.
doi :
10.1074/jbc.274.50.35415 .
PMID
10585411 .
Bushell M, Wood W, Clemens MJ, Morley SJ (2000).
"Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis" . Eur. J. Biochem . 267 (4): 1083–91.
doi :
10.1046/j.1432-1327.2000.01101.x .
PMID
10672017 .
Bushell M, Wood W, Carpenter G, Pain VM, Morley SJ, Clemens MJ (2001).
"Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages" . J. Biol. Chem . 276 (26): 23922–8.
doi :
10.1074/jbc.M100384200 .
PMID
11274152 .
Fleming K, Ghuman J, Yuan X, Simpson P, Szendröi A, Matthews S, Curry S (2003). "Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B". Biochemistry . 42 (30): 8966–75.
doi :
10.1021/bi034506g .
PMID
12885229 .
Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW (2004).
"Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases" . EMBO J . 23 (8): 1761–9.
doi :
10.1038/sj.emboj.7600193 .
PMC
394247 .
PMID
15071500 .
Doepker RC, Hsu WL, Saffran HA, Smiley JR (2004).
"Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H" . J. Virol . 78 (9): 4684–99.
doi :
10.1128/JVI.78.9.4684-4699.2004 .
PMC
387725 .
PMID
15078951 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004).
"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711–8.
doi :
10.1101/gr.2435604 .
PMC
515316 .
PMID
15342556 .
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N (2006).
"The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity" . EMBO J . 25 (12): 2781–91.
doi :
10.1038/sj.emboj.7601166 .
PMC
1500846 .
PMID
16763566 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .