28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a
protein that in humans is encoded by the MRPS5gene.[5]
Function
Mammalianmitochondrialribosomalproteins are encoded by
nuclear genes and help in
protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to
rRNA composition compared to
prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and
prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different
species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence
homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family.
Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.[5]
Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80.
doi:
10.1016/S0888-7543(03)00004-1.
PMID12706105.
Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70.
doi:
10.1006/geno.2001.6622.
PMID11543634.