From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 5 is a
protein that in humans is encoded by the EIF5
gene .
[5]
[6]
EIF5 is a
GTPase-activating protein .
[7]
References
External links
Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)
Further reading
Das S, Maiti T, Das K, Maitra U (1998).
"Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2" . J. Biol. Chem . 272 (50): 31712–8.
doi :
10.1074/jbc.272.50.31712 .
PMID
9395514 .
Bandyopadhyay A, Maitra U (1999).
"Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells" . Nucleic Acids Res . 27 (5): 1331–7.
doi :
10.1093/nar/27.5.1331 .
PMC
148320 .
PMID
9973622 .
Das S, Maitra U (2000).
"Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo" . Mol. Cell. Biol . 20 (11): 3942–50.
doi :
10.1128/MCB.20.11.3942-3950.2000 .
PMC
85746 .
PMID
10805737 .
Choi SK, Olsen DS, Roll-Mecak A, et al. (2000).
"Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2" . Mol. Cell. Biol . 20 (19): 7183–91.
doi :
10.1128/MCB.20.19.7183-7191.2000 .
PMC
86272 .
PMID
10982835 .
Das S, Ghosh R, Maitra U (2001).
"Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein" . J. Biol. Chem . 276 (9): 6720–6.
doi :
10.1074/jbc.M008863200 .
PMID
11092890 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
Asano K, Shalev A, Phan L, et al. (2001).
"Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation" . EMBO J . 20 (9): 2326–37.
doi :
10.1093/emboj/20.9.2326 .
PMC
125443 .
PMID
11331597 .
Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002).
"Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo" . Nucleic Acids Res . 30 (5): 1154–62.
doi :
10.1093/nar/30.5.1154 .
PMC
101238 .
PMID
11861906 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003).
"Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 1535–40.
Bibcode :
2003PNAS..100.1535M .
doi :
10.1073/pnas.0437845100 .
PMC
149867 .
PMID
12569173 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Homma MK, Wada I, Suzuki T, et al. (2005).
"CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression" . Proc. Natl. Acad. Sci. U.S.A . 102 (43): 15688–93.
Bibcode :
2005PNAS..10215688H .
doi :
10.1073/pnas.0506791102 .
PMC
1266118 .
PMID
16227438 .
Conte MR, Kelly G, Babon J, et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors". Biochemistry . 45 (14): 4550–8.
doi :
10.1021/bi052387u .
PMID
16584190 .
Bieniossek C, Schütz P, Bumann M, et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5". J. Mol. Biol . 360 (2): 457–65.
doi :
10.1016/j.jmb.2006.05.021 .
PMID
16781736 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .