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Trade names | Wei Ni An |
Other names | Nylestriol; LY-49825; Ethinylestriol cyclopentyl ether; EE3CPE; 17α-Ethynylestriol 3-cyclopentyl ether |
Routes of administration | By mouth |
Drug class | Estrogen; Estrogen ether |
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Chemical and physical data | |
Formula | C25H32O3 |
Molar mass | 380.528 g·mol−1 |
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Nilestriol ( INN ) (brand name Wei Ni An; developmental code name LY-49825), also known as nylestriol ( USAN , BAN ), is a synthetic estrogen which was patented in 1971 [1] and is marketed in China. [2] [3] It is the 3-cyclopentyl ether of ethinylestriol, and is also known as ethinylestriol cyclopentyl ether (EE3CPE). [4] Nilestriol is a prodrug of ethinylestriol, and is a more potent estrogen in comparison. [4] It is described as a slowly- metabolized, long-acting estrogen and derivative of estriol. [5] [6] Nilestriol was assessed in combination with levonorgestrel for the potential treatment of postmenopausal osteoporosis, but this formulation ultimately was not marketed. [7]