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Immunogen and vaccine against androstenedione
Ovandrotone albumin (
INN Tooltip International Nonproprietary Name ,
BAN Tooltip British Approved Name ) (brand names Fecundin , Ovastim ),
[1] also known as polyandroalbumin , as well as ovandrotone:human serum albumin conjugate , is an
immunogen and
vaccine against
androstenedione that is used in
veterinary medicine to increase the
ovulation rate and number of
lambs born to
ewes .
[2]
[3]
[4]
[5] It is a
conjugate of
ovandrotone (androstenedione-7α-carboxyethylthioether)
[6] and
human serum albumin .
[5] The drug was developed by 1981 and was introduced in
Australia and
New Zealand in 1983.
[4]
[7]
Ovandrotone albumin produces transient
immunity against androstenedione,
[8] and the generation of
antibodies against androstenedione presumably decreases circulating levels of androstenedione.
[7] This is thought to result in reduced
negative feedback on the
hypothalamic-pituitary-gonadal axis and increased
gonadotropin
secretion , which in turn improves
fertility and
fecundity .
[4] Indeed, ovandrotone albumin has been found to significantly increase
luteinizing hormone levels throughout the
estrous cycle in ewes.
[4]
See also
References
^ Sylvester-Bradley R, Wiseman J (1 January 2005).
Yields of Farmed Species: Constraints and Opportunities in the 21st Century . Nottingham University Press. p. 55.
ISBN
978-1-904761-23-5 .
^ Elks J (14 November 2014).
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. p. 908.
ISBN
978-1-4757-2085-3 .
^ Hoskinson RM, Scaramuzzi RJ, Campbell BK, Downing JA, Welch RJ, Harrison BE (1986). "Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle". Immunological Approaches to Contraception and Promotion of Fertility . pp. 351–366.
doi :
10.1007/978-1-4684-5140-5_38 .
ISBN
978-1-4684-5142-9 .
^
a
b
c
d Carnegie PR (1988). "Autoimmunization Against Hormones: A New Strategy in Animal Production". Anti-Idiotypes, Receptors, and Molecular Mimicry . pp. 245–254.
doi :
10.1007/978-1-4612-3734-1_15 .
ISBN
978-1-4612-8325-6 .
^
a
b
International Nonproprietary Names (INN) for biological and biotechnological substances
^
Journal of Animal Science . American Society of Animal Science. 1991. pp. 3931–3932.
^
a
b Sreenan JM, Diskin MG (6 December 2012).
Embryonic Mortality in Farm Animals . Springer Science & Business Media. pp. 172–.
ISBN
978-94-009-5038-2 .
^ Lindsay DR, Pearce DT, eds. (1984). Reproduction in Sheep . Cambridge University Press.
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