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Chemical compound
Levormeloxifene
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Other names | Levomeloxifene; 6720-CDRI; NNC-460020 |
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1-(2-[4-[(3R,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2H-chromen-4-yl]phenoxy]ethyl)pyrrolidine
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PubChem
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CompTox Dashboard (
EPA) | |
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Formula | C30H35NO3 |
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Molar mass | 457.614 g·mol−1 |
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3D model (
JSmol) | |
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O(c1ccc(cc1)[C@@H]3c4c(OC([C@H]3c2ccccc2)(C)C)cc(OC)cc4)CCN5CCCC5
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InChI=1S/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3/t28-,29+/m1/s1 YKey:XZEUAXYWNKYKPL-WDYNHAJCSA-N Y
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Levormeloxifene (
INNTooltip International Nonproprietary Name; developmental code names 6720-CDRI, NNC-460020) is a
selective estrogen receptor modulator (SERM) which was being developed as an alternative to
estrogen replacement therapy for the treatment and prevention of
postmenopausal
bone loss but did not complete development and hence was never marketed.
[1] The development was stopped because of a high incidence of
gynecological
side effects during
clinical trials.
[2] Levormeloxifene is the
levorotatory
enantiomer of
ormeloxifene, which, in contrast, has been marketed, though rather as a
hormonal contraceptive.
See also
References
External links
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3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
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3α,5α-Dihydrolevonorgestrel
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Mixed (
SERMsTooltip Selective estrogen receptor modulators) | |
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Antagonists |
- Coregulator-binding modulators:
ERX-11
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GPERTooltip G protein-coupled estrogen receptor | Agonists | |
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Antagonists | |
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Unknown | |
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