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An α2 adrenoceptor antagonist
Tolazoline is a non-selective
competitive
α-adrenergic receptor antagonist .
[1] It is a
vasodilator that is used to treat spasms of peripheral blood vessels (as in
acrocyanosis ). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe
peripheral vasoconstriction which can occur as a result of
overdose with certain
5-HT2A
agonist drugs such as
25I-NBOMe ,
[2]
DOB and
Bromodragonfly (prolonged severe vasoconstriction can lead to
gangrene if untreated).
[3]
[4]
It is however most commonly used in
veterinary medicine , to reverse
xylazine -induced
sedation .
[5]
[6]
References
^ Aronson, J. K. (2016). Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions . Amsterdam: Elsevier Science.
ISBN
978-0-444-53717-1 .
OCLC
927102885 . Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.
^
"Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935)" . hmdb.ca . Retrieved 2022-02-03 .
^ Bowen JS, Davis GB, Kearney TE, Bardin J (March 1983). "Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion". JAMA . 249 (11): 1477–9.
doi :
10.1001/jama.1983.03330350053028 .
PMID
6827726 .
^ Thorlacius K, Borna C, Personne M (2008). "[Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case]". Läkartidningen (in Swedish). 105 (16): 1199–200.
PMID
18522262 .
^ Boothe DM (2001). "Anticonvulsant drugs and analeptic agents". In Adams HR (ed.).
Veterinary pharmacology and therapeutics . Ames: Iowa State University Press. pp. 378–9.
ISBN
0-8138-1743-9 . Retrieved 8 September 2008 .
^ Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication". Veterinary anaesthesia . Philadelphia: W.B. Saunders. pp. 90–1.
ISBN
0-7020-2035-4 .
α1
Agonists Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g.,
brexpiprazole ,
clozapine ,
olanzapine ,
quetiapine ,
risperidone )
Benoxathian
Beta blockers (e.g.,
adimolol ,
amosulalol ,
arotinolol ,
carvedilol ,
eugenodilol ,
labetalol )
Buflomedil
Bunazosin
Corynanthine
Dapiprazole
Domesticine
Doxazosin
Ergolines (e.g.,
acetergamine ,
ergotamine ,
dihydroergotamine ,
lisuride ,
nicergoline ,
terguride )
Etoperidone
Fenspiride
Hydroxyzine
Indoramin
Ketanserin
L-765,314
mCPP
Mepiprazole
Metazosin
Monatepil
Moxisylyte
Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
Pelanserin
Perlapine
Phendioxan
Phenoxybenzamine
Phentolamine
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Piperoxan
Prazosin
Quinazosin
Quinidine
Silodosin
Spegatrine
Spiperone
Talipexole
Tamsulosin
Terazosin
Tiodazosin
Tolazoline
Tetracyclic antidepressants (e.g.,
amoxapine ,
maprotiline ,
mianserin )
Tricyclic antidepressants (e.g.,
amitriptyline ,
clomipramine ,
doxepin ,
imipramine ,
trimipramine )
Trimazosin
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Urapidil
WB-4101
Zolertine
α2
Agonists Antagonists
1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g.,
asenapine ,
brexpiprazole ,
clozapine ,
lurasidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
zotepine )
Azapirones (e.g.,
buspirone ,
gepirone ,
ipsapirone ,
tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Yohimbine
β