Cetiedil is a
vasodilator and an anti-sickling agent.[1]
Synthesis
The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid,
CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4).
References
^Alavi JB (May 1984). "Sickle cell anemia. Pathophysiology and treatment". The Medical Clinics of North America. 68 (3): 545–56.
doi:
10.1016/s0025-7125(16)31115-4.
PMID6205230.
^Pons, Robba, FR 1460571 and Pons et al., FR M5504 (1966, 1967, both to
Innothera), C.A. 68, 59429d (1968); 71, 91286c (1969).
^Roxburgh, Craig J.; Ganellin, C. Robin; Shiner, Mark A. R.; Benton, David C. H.; Dunn, Philip M.; Ayalew, Yeshi; Jenkinson, Donald H. (1996). "The Synthesis and Some Pharmacological Actions of the Enantiomers of the K+-Channel Blocker Cetiedil". Journal of Pharmacy and Pharmacology. 48 (8): 851–859. doi:10.1111/j.2042-7158.1996.tb03986.x.
^Roxburgh, Craig J.; Ganellin, C. Robin; Athmani, Salah; Bisi, Alessandra; Quaglia, Wilma; Benton, David C. H.; Shiner, Mark A. R.; Malik-Hall, Misbah; Haylett, Dennis G.; Jenkinson, Donald H. (2001). "Synthesis and Structure−Activity Relationships of Cetiedil Analogues as Blockers of the Ca2+-Activated K+Permeability of Erythrocytes†". Journal of Medicinal Chemistry. 44 (20): 3244–3253. doi:10.1021/jm001113w.