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Indenolol
Names
IUPAC name
1-(1H -Inden-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Identifiers
ChEMBL
ChemSpider
DrugBank
EC Number
KEGG
UNII
InChI=1S/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
Key: MPGBPFMOOXKQRX-UHFFFAOYSA-N
InChI=1/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
Key: MPGBPFMOOXKQRX-UHFFFAOYAY
CC(C)NCC(COC1=CC=CC2=C1C=CC2)O
Properties
C 15 H 21 N O 2
Molar mass
247.338 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Indenolol is a
beta-adrenergic blocker
[1] for the treatment of
hypertension (high blood pressure). It was investigated in the 1980s,
[2] but is not known to be marketed as of 2021
[update] .
[3] It is a derivative of a phenolic 4-
indenol .
References
^ Ali, I; Gaitonde, VD; Aboul-Enein, HY; Hussain, A (2009). "Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC". Talanta . 78 (2): 458–63.
doi :
10.1016/j.talanta.2008.11.043 .
PMID
19203609 .
^ Trimarco, Bruno; Cuocolo, Alberto; Groothold, Gisela; Ricciardelli, Bruno; De Luca, Nicola; Volpe, Massimo; Veniero, Anna Maria; Condorelli, Mario (1985). "Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double-Blind Study with Metoprolol". The Journal of Clinical Pharmacology . 25 (5): 328–336.
doi :
10.1002/j.1552-4604.1985.tb02850.x .
PMID
4031109 .
S2CID
22844379 .
^
DrugBank
DB08952
. Accessed 2021-03-18.
α1
Agonists Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g.,
brexpiprazole ,
clozapine ,
olanzapine ,
quetiapine ,
risperidone )
Benoxathian
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amosulalol ,
arotinolol ,
carvedilol ,
eugenodilol ,
labetalol )
Buflomedil
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Corynanthine
Dapiprazole
Domesticine
Doxazosin
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acetergamine ,
ergotamine ,
dihydroergotamine ,
lisuride ,
nicergoline ,
terguride )
Etoperidone
Fenspiride
Hydroxyzine
Indoramin
Ketanserin
L-765,314
mCPP
Mepiprazole
Metazosin
Monatepil
Moxisylyte
Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
Pelanserin
Perlapine
Phendioxan
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antidepressants (e.g.,
hydroxynefazodone ,
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triazoledione )
Piperoxan
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Urapidil
WB-4101
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α2
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1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g.,
asenapine ,
brexpiprazole ,
clozapine ,
lurasidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
zotepine )
Azapirones (e.g.,
buspirone ,
gepirone ,
ipsapirone ,
tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Yohimbine
β