Vincamine is a monoterpenoid
indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be
synthesized from related alkaloids.[1]
Uses
Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia.[citation needed] In the United States, it is permitted to be sold as a dietary supplement when labeled for use in adults for six months or less.[2] Most common preparations are in the
sustained release tablet forms.
Chemistry
Synthesis
Tabersonine can be used for semi-synthesis of vincamine.[3]
Derivatives
Vinpocetine is a synthetic
derivative of vincamine used for cerebrovascular diseases and as dietary supplement.[4] Vincamine derivatives have been also studied as anti addictive[5] and antidiabetic[6] agents.
Research
It may have
nootropic effects.[3] It has been investigated as novel anticancer drug.[7]
Chemical Selection Working Group.
"Vincamine - 1617-90-9"(PDF). Summary of Data for Chemical Selection. NIH - United States National Institutes of Health.
Archived(PDF) from the original on 2011-10-21. Retrieved 2007-04-23.