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Cicloprolol
Names
IUPAC name
1-[4-[2-(Cyclopropylmethoxy)ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
Identifiers
ChEMBL
ChemSpider
KEGG
UNII
InChI=1S/C18H29NO4/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3
Key: JNDJPKHYZWRRIS-UHFFFAOYSA-N
CC(C)NCC(COC1=CC=C(C=C1)OCCOCC2CC2)O
Properties
C 18 H 29 N O 4
Molar mass
323.433 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Cicloprolol is a
beta-adrenoceptor antagonist .
[1]
Synthesis
Cicloprolol synthesis:
[2]
[3]
See also
References
^ Cocco, G; Alfiero, R; Pouleur, H (1992).
"An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure" . Clinical Cardiology . 15 (1): 38–42.
doi :
10.1002/clc.4960150109 .
PMID
1347258 .
^
DE 2649605 , Manoury, Philippe Michel Jacques; Cavero, Icilio Angelo Girolamo & Majer, Henry et al., "Phenoläther, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimttel [Phenol ethers, processes for their preparation and medicinal products containing them]", published 1977-05-18, assigned to
Synthelabo S.A.
^ P. M. J. Manouri, I. A. G. Carero, H. Majer, and P. R. L. Giudicelli, (1977) Chem. Abstr., 87:134,543j (1977). eidem
U.S. patent 4,311,708
α1
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β