From Wikipedia, the free encyclopedia
Chemical compound
Quinelorane
(5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine
CAS Number
PubChem
CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (
EPA )
Formula C 14 H 22 N 4
Molar mass 246.358 g·mol−1 3D model (
JSmol )
CCCN1CCC[C@H]2[C@H]1CC3=CN=C(N=C3C2)N
InChI=1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1
N Key:TUFADSGTJUOBEH-ZWNOBZJWSA-N
N
N Y
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(verify)
Quinelorane is a drug which acts as a
dopamine agonist for the
D2
[1]
[2]
[3] and
D3 receptor.
See also
References
^ Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E (April 2002).
"Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists" . Journal of Neuroscience . 22 (7): 2977–88.
doi :
10.1523/JNEUROSCI.22-07-02977.2002 .
PMC
6758322 .
PMID
11923462 .
^ Gasior M, Paronis CA, Bergman J (January 2004). "Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys". The Journal of Pharmacology and Experimental Therapeutics . 308 (1): 249–59.
doi :
10.1124/jpet.103.052795 .
PMID
14563783 .
S2CID
5879400 .
^ Brooks JM, Sarter M, Bruno JP (September 2007).
"D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortex" . Neuropharmacology . 53 (3): 455–63.
doi :
10.1016/j.neuropharm.2007.06.006 .
PMC
2000917 .
PMID
17681559 .