Small Cajal body specific RNA 24 | |
---|---|
Identifiers | |
Symbol | SCARNA24 |
Alt. Symbols | snoACA12 |
Rfam | RF00422 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0015030 GO:0005730 |
SO | SO:0000275 |
PDB structures | PDBe |
Small Cajal body specific RNA 24 (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation ( isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]
ACA12 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1 protein. [2] ACA12 is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA. [2] [3]