From Wikipedia, the free encyclopedia
In
molecular biology , Small Cajal body specific RNA 13 (also known as scaRNA13 or U93 ) is a
small nucleolar RNA found in
Cajal bodies and believed to be involved in the
pseudouridylation of
U2 and
U5 spliceosomal RNA .
scaRNAs are a specific class of
small nucleolar RNAs that localise to the
Cajal bodies and guide the modification of
RNA polymerase II transcribed
spliceosomal RNAs
U1 ,
U2 ,
U4 ,
U5 and
U12 .
[1]
U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the
H/ACA box class of guide RNAs.
[2] U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5.
[2]
[3]
[4]
References
^ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002).
"Cajal body-specific small nuclear RNAs: A novel class of 2'-O -methylation and pseudouridylation guide RNAs" .
The EMBO Journal . 21 (11): 2746–2756.
doi :
10.1093/emboj/21.11.2746 .
PMC
126017 .
PMID
12032087 .
^
a
b Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002).
"A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains" . Nucleic Acids Res . 30 (21): 4643–9.
doi :
10.1093/nar/gkf592 .
PMC
135803 .
PMID
12409454 .
^ Lestrade, Laurent; Weber, Michel J. (2006).
"snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs" .
Nucleic Acids Research . 34 (Supplement 1: Database Issue): D158–D162.
CiteSeerX
10.1.1.105.7552 .
doi :
10.1093/nar/gkj002 .
PMC
1347365 .
PMID
16381836 .
^ Schattner P, Barberan-Soler S, Lowe TM (2006).
"A computational screen for mammalian pseudouridylation guide H/ACA RNAs" . RNA . 12 (1): 15–25.
doi :
10.1261/rna.2210406 .
PMC
1370881 .
PMID
16373490 .
External links