Small Cajal body specific RNA 15 | |
---|---|
Identifiers | |
Symbol | SCARNA15 |
Alt. Symbols | snoACA45 |
Rfam | RF00426 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0015030 GO:0005730 |
SO | SO:0000275 |
PDB structures | PDBe |
Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation ( isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]
ACA45 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1. [2] ACA45 is predicted to guide the pseudouridylation of residue U37 of the U2 spliceosomal snRNA. [3]
It has been shown that human ACA45 can be processed into a 21 nucleotides long mature miRNA by the RNAse III family endoribonuclease dicer. [4] This snoRNA product has previously been identified as mmu-miR-1839 [5] and was shown to be processed independent of the other miRNA generating endoribonuclease drosha. [6]