Small Cajal body specific RNA 16 | |
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Identifiers | |
Symbol | SCARNA16 |
Alt. Symbols | snoACA47 |
Rfam | RF00424 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0005730 |
SO | SO:0000275 |
PDB structures | PDBe |
Small Cajal body specific RNA 16 (also known as SCARNA16 or ACA47) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation ( isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]
ACA47 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1. [2] ACA47 is predicted to guide the pseudouridylation of residue U5 of the U1 spliceosomal snRNA. [3]