| Small Cajal body specific RNA 11 | |
|---|---|
 Predicted
secondary structure and
sequence conservation of SCARNA11 | |
| Identifiers | |
| Symbol | SCARNA11 |
| Alt. Symbols | snoACA57 |
| Rfam | RF00564 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0015030 GO:0005730 |
| SO | SO:0000275 |
| PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 11 (also known as scaRNA11 or ACA57) is a small nucleolar RNA found in Cajal bodies.
scaRNAs are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1] [2] ACA57 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1. [1] ACA57 is predicted to guide the pseudouridylation of the U5 spliceosomal RNA at position U43. [3]
References
- ^ a b Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi: 10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
- ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi: 10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ^ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi: 10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
External links
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