From Wikipedia, the free encyclopedia
Chemical compound
Talsupram (Lu 5-005 or Lu 5-003
[1] ) is a
selective
norepinephrine reuptake inhibitor (NRI) which was investigated as an
antidepressant in the 1960s and 1970s but was never marketed.
[2]
[3]
[4] Along with
talopram , it is
structurally related to the
selective serotonin reuptake inhibitor (SSRI)
citalopram .
[5]
See also
References
^ Carlsson A, Fuxe K, Hamberger B, Malmfors T (May 1969).
"Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro" . British Journal of Pharmacology . 36 (1): 18–28.
doi :
10.1111/j.1476-5381.1969.tb08299.x .
ISSN
0007-1188 .
OCLC
6895508396 .
PMC
1703539 .
PMID
5768100 .
^ Pawłowski L, Mazela H (June 1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology . 88 (2): 240–246.
doi :
10.1007/BF00652248 .
ISSN
0033-3158 .
OCLC
5653283278 .
PMID
3006113 .
S2CID
1732297 .
^ McConathy J, Owens MJ, Kilts CD, et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology . 31 (6): 705–18.
doi :
10.1016/j.nucmedbio.2003.05.001 .
PMID
15246361 .
^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology . 28 (3): 332–47.
doi :
10.1016/S0306-4530(02)00026-4 .
PMID
12573300 .
S2CID
23452713 .
^
"The SSRI Issues" (DOC) . healyprozac.com . Retrieved January 3, 2024 .
SSRIs Tooltip Selective serotonin reuptake inhibitors
SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors
NRIs Tooltip Norepinephrine reuptake inhibitors
NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants
SARIs Tooltip Serotonin antagonist and reuptake inhibitors
SMS Tooltip Serotonin modulator and stimulators Others
TCAs Tooltip Tricyclic antidepressants
TeCAs Tooltip Tetracyclic antidepressants Others
Non-selective
MAOA Tooltip Monoamine oxidase A -selective
MAOB Tooltip Monoamine oxidase B -selective
DAT Tooltip Dopamine transporter (
DRIs Tooltip Dopamine reuptake inhibitors )
NET Tooltip Norepinephrine transporter (
NRIs Tooltip Norepinephrine reuptake inhibitors )
Others:
Antihistamines (e.g.,
brompheniramine ,
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pheniramine ,
tripelennamine )
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loxapine ,
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ketamine ,
phencyclidine )
Dopexamine
Ephenidine
Ginkgo biloba
Indeloxazine
Nefazodone
Opioids (e.g.,
desmetramadol ,
methadone ,
pethidine (meperidine) ,
tapentadol ,
tramadol ,
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SERT Tooltip Serotonin transporter (
SRIs Tooltip Serotonin reuptake inhibitors )
Others:
A-80426
Amoxapine
Antihistamines (e.g.,
brompheniramine ,
chlorphenamine ,
dimenhydrinate ,
diphenhydramine ,
mepyramine (pyrilamine) ,
pheniramine ,
tripelennamine )
Antipsychotics (e.g.,
loxapine ,
ziprasidone )
Arylcyclohexylamines (e.g.,
3-MeO-PCP ,
esketamine ,
ketamine ,
methoxetamine ,
phencyclidine )
Cyclobenzaprine
Delucemine
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Dextrorphan
Efavirenz
Hypidone
Medifoxamine
Mesembrine
Mifepristone
MIN-117 (WF-516)
N-Me-5-HT
Opioids (e.g.,
dextropropoxyphene ,
methadone ,
pethidine (meperidine) ,
levorphanol ,
tapentadol ,
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Roxindole
VMATs Tooltip Vesicular monoamine transporters Others