Simmondsin is a component of
jojoba seeds (pronounced "ho-HO-bah") (Simmondsia chinensis). While it had been considered toxic due to jojoba seed meal causing weight loss in animals, in recent years its
appetite suppressant effect has also been researched as a potential treatment for obesity.[1] It is thought to reduce appetite by increasing levels of
cholecystokinin.[2][3][4][5]
^Cokelaere MM, Busselen P, Flo G, Daenens P, Decuypere E, Kühn E, Van Boven M (December 1995). "Devazepide reverses the anorexic effect of simmondsin in the rat". The Journal of Endocrinology. 147 (3): 473–7.
doi:
10.1677/joe.0.1470473.
PMID8543917.
^Flo G, Vermaut S, Van Boven M, Daenens P, Buyse J, Decuypere E, et al. (August 1998). "Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food-restricted rats". Hormone and Metabolic Research. 30 (8): 504–8.
doi:
10.1055/s-2007-978921.
PMID9761380.
S2CID260166054.
^Flo G, Van Boven M, Vermaut S, Daenens P, Decuypere E, Cokelaere M (April 2000). "The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat". Appetite. 34 (2): 147–51.
doi:
10.1006/appe.1999.0299.
PMID10744903.
S2CID42949049.