From Wikipedia, the free encyclopedia
Propionate kinase (
EC
2.7.2.15 , PduW , TdcD , propionate/acetate kinase ) is an
enzyme with
systematic name ATP:propanoate phosphotransferase .
[1]
[2]
[3]
[4]
[5]
[6] This enzyme
catalyses the following
chemical reaction
ATP +
propanoate
⇌
{\displaystyle \rightleftharpoons }
ADP + propanoyl phosphate
This enzyme requires Mg2+ .
References
^ Hesslinger C, Fairhurst SA, Sawers G (January 1998). "Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate". Molecular Microbiology . 27 (2): 477–92.
doi :
10.1046/j.1365-2958.1998.00696.x .
PMID
9484901 .
^ Palacios S, Starai VJ, Escalante-Semerena JC (May 2003).
"Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol" . Journal of Bacteriology . 185 (9): 2802–10.
doi :
10.1128/jb.185.9.2802-2810.2003 .
PMC
154405 .
PMID
12700259 .
^ Wei Y, Miller CG (October 1999).
"Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium" . Journal of Bacteriology . 181 (19): 6092–7.
PMC
103637 .
PMID
10498722 .
^ Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG (April 2005).
"Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase" . Journal of Bacteriology . 187 (7): 2386–94.
doi :
10.1128/jb.187.7.2386-2394.2005 .
PMC
1065240 .
PMID
15774882 .
^ Simanshu DK, Murthy MR (January 2005).
"Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium" . Acta Crystallographica Section F . 61 (Pt 1): 52–5.
doi :
10.1107/s1744309104026429 .
PMC
1952409 .
PMID
16508089 .
^ Simanshu DK, Savithri HS, Murthy MR (September 2005). "Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily". Journal of Molecular Biology . 352 (4): 876–92.
doi :
10.1016/j.jmb.2005.07.069 .
PMID
16139298 .
External links
Activity Regulation Classification Kinetics Types