DNA-directed DNA polymerase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.7.7 | ||||||||
CAS no. | 9012-90-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4. [1] DNA Pol δ is an enzyme used for both leading and lagging strand synthesis. [2] [3] It exhibits increased processivity when interacting with the proliferating cell nuclear antigen ( PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.[ citation needed]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.