Phosphofructokinase, platelet, also known as PFKP is an
enzyme which in humans is encoded by the PFKPgene.[5]
Function
The PFKP gene encodes the platelet isoform of
phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of
fructose 6-phosphate to
fructose 1,6-bisphosphate and is a key regulatory enzyme in
glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (
PFKM) and liver (
PFKL) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[5][6]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Kahn A, Meienhofer MC, Cottreau D, et al. (1979). "Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues". Hum. Genet. 48 (1): 93–108.
doi:
10.1007/bf00273280.
PMID156693.
S2CID23300861.
Morrison N, Simpson C, Fothergill-Gilmore L, et al. (1992). "Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15". Hum. Genet. 89 (1): 105–6.
doi:
10.1007/BF00207053.
PMID1533608.
S2CID42022687.
Simpson CJ, Fothergill-Gilmore LA (1991). "Isolation and sequence of a cDNA encoding human platelet phosphofructokinase". Biochem. Biophys. Res. Commun. 180 (1): 197–203.
doi:
10.1016/S0006-291X(05)81276-8.
PMID1834056.
Eto K, Sakura H, Yasuda K, et al. (1994). "Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet". Biochem. Biophys. Res. Commun. 198 (3): 990–8.
doi:
10.1006/bbrc.1994.1141.
PMID8117307.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46.
doi:
10.1002/pmic.200300528.
PMID14760703.
S2CID8868600.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Hannemann A, Jandrig B, Gaunitz F, et al. (2005). "Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines". Gene. 345 (2): 237–47.
doi:
10.1016/j.gene.2004.11.018.
PMID15716112.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
Overview of all the structural information available in the
PDB for
UniProt: Q01813 (Human ATP-dependent 6-phosphofructokinase, platelet type) at the
PDBe-KB.