From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
POLK
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1T94 ,
2LSI ,
2OH2 ,
2W7O ,
2W7P ,
3IN5 ,
3PZP ,
4BA9 ,
4GK5 ,
4U6P ,
4U7C
Identifiers
Aliases
POLK , DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappaExternal IDs
OMIM :
605650 ;
MGI :
1349767 ;
HomoloGene :
32140 ;
GeneCards :
POLK ;
OMA :
POLK - orthologs
Wikidata
DNA polymerase kappa is a
DNA polymerase that in humans is encoded by the POLK
gene . It is involved in
translesion synthesis .
[4]
[5]
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000122008 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000).
"Error-prone bypass of certain DNA lesions by the human DNA polymerase κ" . Genes Dev . 14 (13): 1589–94.
doi :
10.1101/gad.14.13.1589 .
PMC
316741 .
PMID
10887153 .
^ Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999).
"Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily" . Proc Natl Acad Sci U S A . 96 (21): 11922–7.
Bibcode :
1999PNAS...9611922G .
doi :
10.1073/pnas.96.21.11922 .
PMC
18388 .
PMID
10518552 .
^
"Entrez Gene: POLK Polymerase (DNA directed) kappa" .
Further reading
Bavoux C, Hoffmann JS, Cazaux C (2005). "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa". Biochimie . 87 (7): 637–46.
doi :
10.1016/j.biochi.2005.02.007 .
PMID
15989980 .
Ogi T, Kato T, Kato T, Ohmori H (2000).
"Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB" . Genes Cells . 4 (11): 607–18.
doi :
10.1046/j.1365-2443.1999.00289.x .
PMID
10620008 .
S2CID
6554870 .
Johnson RE, Prakash S, Prakash L (2000).
"The human DINB1 gene encodes the DNA polymerase Polθ" . Proc. Natl. Acad. Sci. U.S.A . 97 (8): 3838–43.
Bibcode :
2000PNAS...97.3838J .
doi :
10.1073/pnas.97.8.3838 .
PMC
18103 .
PMID
10760255 .
Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC (2001).
"Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene" . J. Biol. Chem . 276 (1): 92–8.
doi :
10.1074/jbc.M004413200 .
PMID
11024016 .
Haracska L, Unk I, Johnson RE, et al. (2002).
"Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA" . Mol. Cell. Biol . 22 (3): 784–91.
doi :
10.1128/MCB.22.3.784-791.2002 .
PMC
133560 .
PMID
11784855 .
Washington MT, Johnson RE, Prakash L, Prakash S (2002).
"Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini" . Proc. Natl. Acad. Sci. U.S.A . 99 (4): 1910–4.
Bibcode :
2002PNAS...99.1910W .
doi :
10.1073/pnas.032594399 .
PMC
122293 .
PMID
11842189 .
Suzuki N, Ohashi E, Kolbanovskiy A, et al. (2002). "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)". Biochemistry . 41 (19): 6100–6.
doi :
10.1021/bi020049c .
PMID
11994005 .
Fischhaber PL, Gerlach VL, Feaver WJ, et al. (2002).
"Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides" . J. Biol. Chem . 277 (40): 37604–11.
doi :
10.1074/jbc.M206027200 .
PMID
12145297 .
Bergoglio V, Bavoux C, Verbiest V, et al. (2003). "Localisation of human DNA polymerase kappa to replication foci". J. Cell Sci . 115 (Pt 23): 4413–8.
doi :
10.1242/jcs.00162 .
PMID
12414988 .
S2CID
84437951 .
Haracska L, Prakash L, Prakash S (2003).
"Role of human DNA polymerase κ as an extender in translesion synthesis" . Proc. Natl. Acad. Sci. U.S.A . 99 (25): 16000–5.
doi :
10.1073/pnas.252524999 .
PMC
138554 .
PMID
12444249 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Wolfle WT, Washington MT, Prakash L, Prakash S (2003).
"Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions" . Genes Dev . 17 (17): 2191–9.
doi :
10.1101/gad.1108603 .
PMC
196459 .
PMID
12952891 .
Haracska L, Prakash L, Prakash S (2003).
"A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair" . Genes Dev . 17 (22): 2777–85.
doi :
10.1101/gad.1146103 .
PMC
280626 .
PMID
14630940 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Suzuki N, Itoh S, Poon K, et al. (2004). "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa". Biochemistry . 43 (20): 6304–11.
doi :
10.1021/bi0360298 .
PMID
15147214 .
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells . 9 (6): 523–31.
doi :
10.1111/j.1356-9597.2004.00747.x .
PMID
15189446 .
S2CID
24470762 .
Washington MT, Minko IG, Johnson RE, et al. (2004).
"Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ" . Mol. Cell. Biol . 24 (13): 5687–93.
doi :
10.1128/MCB.24.13.5687-5693.2004 .
PMC
480884 .
PMID
15199127 .
Uljon SN, Johnson RE, Edwards TA, et al. (2005).
"Crystal structure of the catalytic core of human DNA polymerase kappa" . Structure . 12 (8): 1395–404.
doi :
10.1016/j.str.2004.05.011 .
PMID
15296733 .
External links
Overview of all the structural information available in the
PDB for
UniProt :
Q9UBT6 (DNA polymerase kappa) at the
PDBe-KB .